MedKoo Cat#: 562926 | Name: TFMB-(R)-2-HG
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TFMB-(R)-2-HG is a cell membrane-permeable version of (R)-2-HG that acts as a promoter of leukemogenesis, dose-dependently and passage-dependently blocking differentiation.

Chemical Structure

TFMB-(R)-2-HG
CAS#1445700-01-5

Theoretical Analysis

MedKoo Cat#: 562926

Name: TFMB-(R)-2-HG

CAS#: 1445700-01-5

Chemical Formula: C13H11F3O4

Exact Mass: 288.0609

Molecular Weight: 288.22

Elemental Analysis: C, 54.17; H, 3.85; F, 19.77; O, 22.20

Price and Availability

Size Price Availability Quantity
1mg USD 230.00
5mg USD 470.00
10mg USD 780.00
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Related CAS #
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Synonym
TFMB-(R)-2-HG; TFMB (R) 2 HG; TFMB(R)2HG; TFMB R 2 HG; TFMBR2HG;
IUPAC/Chemical Name
(2R)-Tetrahydro-5-oxo-2-furancarboxylic acid [3-(trifluoromethyl)phenyl]methyl ester
InChi Key
UXTLNUGKDZMPTC-SNVBAGLBSA-N
InChi Code
InChI=1S/C13H11F3O4/c14-13(15,16)9-3-1-2-8(6-9)7-19-12(18)10-4-5-11(17)20-10/h1-3,6,10H,4-5,7H2/t10-/m1/s1
SMILES Code
O=C([C@@H](CC1)OC1=O)OCC2=CC=CC(C(F)(F)F)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 288.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Losman JA, Looper RE, Koivunen P, Lee S, Schneider RK, McMahon C, Cowley GS, Root DE, Ebert BL, Kaelin WG Jr. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013 Mar 29;339(6127):1621-5. doi: 10.1126/science.1231677. Epub 2013 Feb 7. PubMed PMID: 23393090; PubMed Central PMCID: PMC3836459.