MedKoo Cat#: 555779 | Name: WUN29654
Featured New

Description:

WARNING: This product is for research use only, not for human or veterinary use.

WUN29654 is a CRBN modulator, which showed CRBN modulatory activity with IC50 value of 2.6μM, Ki value of 0.7μM and cell proliferation IC50 vale of ~21.53μM. WUN29654 was reported in patent WO 2020006262 (compound II). This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

WUN29654
WUN29654
CAS#2407829-65-4

Theoretical Analysis

MedKoo Cat#: 555779

Name: WUN29654

CAS#: 2407829-65-4

Chemical Formula: C17H12N2O5

Exact Mass: 324.0746

Molecular Weight: 324.29

Elemental Analysis: C, 62.96; H, 3.73; N, 8.64; O, 24.67

Price and Availability

Size Price Availability Quantity
5mg USD 150.00 Ready to ship
10mg USD 250.00 Ready to ship
25mg USD 450.00 Ready to ship
50mg USD 750.00 Ready to ship
100mg USD 1,250.00 Ready to ship
200mg USD 1,950.00 Ready to ship
Show More
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
Synonym
WUN29654; WUN-29654; WUN 29654;
IUPAC/Chemical Name
2-(2,6-dioxopiperidin-3-yl)-5-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione
InChi Key
WGTKYDFLBDSIPX-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H12N2O5/c20-9-6-8-2-1-3-10-14(8)11(7-9)17(24)19(16(10)23)12-4-5-13(21)18-15(12)22/h1-3,6-7,12,20H,4-5H2,(H,18,21,22)
SMILES Code
O=C(C1=C2C(C=C(O)C=C23)=CC=C1)N(C4CCC(NC4=O)=O)C3=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Biological target:
WUN29654 is a CRBN modulator, which showed CRBN modulatory activity with IC50 value of 2.6μM, Ki value of 0.7μM and cell proliferation IC50 vale of ~21.53μM.
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 324.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Gray, Nathanael; Zhang, Tinghu; Fischer, Eric; Verano, Alyssa; He, Zhixiang; Du, Guangyan; Donovan, Katherine; Nowak, Radoslaw; Yuan, Christine. 2-​(2,​6-​Dioxopiperidin-​3-​yl)​benzo[de]​isoquinoline-​1,​3(2H)​-​diones as CRBN modulators and their preparation. PCT Int. Appl. (2020), WO 2020006262.