Cortexolone, also known as 11-deoxycortisol, is antiglucocorticoid agent. Cortexolone is also an active metabolite of Clascoterone (CB-03-01). In rat thymocytes, cortexolone competes for binding to glucocorticoid receptors, as identified on sucrose density gradients, and blocks the effect of triamcinolone acetonide (TA) on 2-deoxyglucose uptake.
MedKoo Cat#: 330030
Name: Cortexolone
CAS#: 152-58-9
Chemical Formula: C21H30O4
Exact Mass: 346.2144
Molecular Weight: 346.47
Elemental Analysis: C, 72.80; H, 8.73; O, 18.47
The following data is based on the product molecular weight 346.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
