Desethylchloroquine, also known as (±)-Desethylchloroquine, is a major active metabolite of chloroquine formed when chloroquine undergoes dealkylation, primarily by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 and to a lesser extent by CYP2D6. It inhibits the growth of the P. falciparum strain LA136 in vitro.
MedKoo Cat#: 534307
Name: Desethylchloroquine
CAS#: 1476-52-4 (racemate)
Chemical Formula: C16H22ClN3
Exact Mass: 291.1502
Molecular Weight: 291.82
Elemental Analysis: C, 65.85; H, 7.60; Cl, 12.15; N, 14.40
The following data is based on the product molecular weight 291.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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