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MedKoo Cat#: 555770 | Name: TT-OAD2 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TT-OAD2 is a non-peptide GLP-1 agonist. TT-OAD2 bounds to the glucagon-like peptide-1 (GLP-1) receptor. TT-OAD2 exhibits biased agonism, and kinetics of G-protein activation and signalling that are distinct from peptide agonists.

Chemical Structure

TT-OAD2 HCl
TT-OAD2 HCl
CAS#2382719-60-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 555770

Name: TT-OAD2 HCl

CAS#: 2382719-60-8 (HCl)

Chemical Formula: C50H48Cl3N3O6

Exact Mass:

Molecular Weight: 893.30

Elemental Analysis: C, 67.23; H, 5.42; Cl, 11.91; N, 4.70; O, 10.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1246826-07-2 (free base) 2382719-60-8 (HCl)
Synonym
TT-OAD2; TT-OAD-2; TT-OAD 2; TT-OAD2 HCl; TT-OAD2 hydrochloride
IUPAC/Chemical Name
L-Phenylalanine, N-[[(3S,8S)-3-[4-[(3,4-dichlorophenyl)methoxy]phenyl]-2,3,6,7,8,9-hexahydro-7-[(1S)-1-phenylpropyl]-1,4-dioxino[2,3-g]isoquinolin-8-yl]carbonyl]-4-(2,3-dimethyl-4-pyridinyl)-, hydrochloride
InChi Key
WRWXSSFMSBFJTG-PTIBXWAZSA-N
InChi Code
InChI=1S/C50H47Cl2N3O6.ClH/c1-4-44(35-8-6-5-7-9-35)55-27-38-26-47-46(60-29-48(61-47)36-15-17-39(18-16-36)59-28-33-12-19-41(51)42(52)22-33)25-37(38)24-45(55)49(56)54-43(50(57)58)23-32-10-13-34(14-11-32)40-20-21-53-31(3)30(40)2;/h5-22,25-26,43-45,48H,4,23-24,27-29H2,1-3H3,(H,54,56)(H,57,58);1H/t43-,44-,45-,48+;/m0./s1
SMILES Code
O=C(O)[C@H](CC1=CC=C(C2=C(C)C(C)=NC=C2)C=C1)NC([C@H]3N([C@H](C4=CC=CC=C4)CC)CC5=C(C=C(OC[C@H](C6=CC=C(OCC7=CC=C(Cl)C(Cl)=C7)C=C6)O8)C8=C5)C3)=O.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Class B G-protein-coupled receptors are major targets for the treatment of chronic diseases, including diabetes and obesity. Structures of active receptors reveal peptide agonists engage deep within the receptor core, leading to an outward movement of extracellular loop 3 and the tops of transmembrane helices 6 and 7, an inward movement of transmembrane helix 1, reorganization of extracellular loop 2 and outward movement of the intracellular side of transmembrane helix 6, resulting in G-protein interaction and activation.

Preparing Stock Solutions

The following data is based on the product molecular weight 893.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Zhao P, Liang YL, Belousoff MJ, et al. Activation of the GLP-1 receptor by a non-peptidic agonist. Nature. 2020;577(7790):432–436. doi:10.1038/s41586-019-1902-z