VUF10460 is a potent and selective antagonist of the histamine H4 receptor (H4R), a G protein-coupled receptor critically involved in immune regulation and inflammatory signaling. By effectively inhibiting H4R activity, VUF10460 attenuates histamine-mediated chemotaxis and pro-inflammatory cytokine release, offering a valuable tool for dissecting the complexities of histaminergic immune modulation.
MedKoo Cat#: 555751
Name: VUF10460
CAS#: 1028327-66-3
Chemical Formula: C15H19N5
Exact Mass: 269.1640
Molecular Weight: 269.35
Elemental Analysis: C, 66.89; H, 7.11; N, 26.00
The following data is based on the product molecular weight 269.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
