GSK2818713 | CAS#1422484-32-9 | NS5A HCV inhibitor

MedKoo Cat#: 555746 | Name: GSK2818713

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK2818713 is a Novel Biphenylene Scaffold-Based Hepatitis C NS5A Replication Complex Inhibitor with Broad Genotype Coverage.

Chemical Structure

GSK2818713

CAS#1422484-32-9

Theoretical Analysis

MedKoo Cat#: 555746

Name: GSK2818713

CAS#: 1422484-32-9

Chemical Formula: C46H56N8O8

Exact Mass: 848.4221

Molecular Weight: 849.00

Elemental Analysis: C, 65.08; H, 6.65; N, 13.20; O, 15.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

GSK2818713; GSK-2818713; GSK 2818713;

IUPAC/Chemical Name

dimethyl ((2S,2'S,3R,3'R)-((2S,2'S,3aS,3a'S,6aS,6a'S)-(biphenylene-2,6-diylbis(1H-imidazole-5,2-diyl))bis(hexahydrocyclopenta[b]pyrrole-2,1(2H)-diyl))bis(3-methoxy-1-oxobutane-1,2-diyl))dicarbamate

InChi Key

PJGLLJHUBRGNEG-KDDSMZEWSA-N

InChi Code

InChI=1S/C46H56N8O8/c1-23(59-3)39(51-45(57)61-5)43(55)53-35-11-7-9-27(35)19-37(53)41-47-21-33(49-41)25-13-15-29-31(17-25)30-16-14-26(18-32(29)30)34-22-48-42(50-34)38-20-28-10-8-12-36(28)54(38)44(56)40(24(2)60-4)52-46(58)62-6/h13-18,21-24,27-28,35-40H,7-12,19-20H2,1-6H3,(H,47,49)(H,48,50)(H,51,57)(H,52,58)/t23-,24-,27+,28+,35+,36+,37+,38+,39+,40+/m1/s1

SMILES Code

C[C@@H](OC)[C@H](NC(OC)=O)C(N1[C@]2([H])[C@](CCC2)([H])C[C@H]1C3=NC=C(C4=CC5=C6C=CC(C7=CN=C([C@@H]8C[C@@](CCC9)([H])[C@@]9([H])N8C([C@@H](NC(OC)=O)[C@H](OC)C)=O)N7)=CC6=C5C=C4)N3)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 849.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

GSK2818713, a Novel Biphenylene Scaffold-Based Hepatitis C NS5A Replication Complex Inhibitor with Broad Genotype Coverage Wieslaw M. Kazmierski*Sam Baskaran*Jill T. WalkerNagaraju MiriyalaRamu MeesalaMallesh BeesuGeorge AdjabengRichard M. GrimesRobert HamatakeMartin R. LeiversRenae CrosbyBing XiaKatja Remlinger Cite this: J. Med. Chem. 2020, XXXX, XXX, XXX-XXX Publication Date:March 23, 2020 https://doi-org.proxy2.library.illinois.edu/10.1021/acs.jmedchem.9b02176