HI-253 | CAS#149486-73-7 | HIV Inhibitor

MedKoo Cat#: 563835 | Name: HI-253

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HI-253 is a potent non-nucleoside inhibitor of drug-resistant human immunodeficiency virus (HIV).

Chemical Structure

HI-253

CAS#149486-73-7

Theoretical Analysis

MedKoo Cat#: 563835

Name: HI-253

CAS#: 149486-73-7

Chemical Formula: C14H13BrClN3S

Exact Mass: 368.9702

Molecular Weight: 370.69

Elemental Analysis: C, 45.36; H, 3.54; Br, 21.56; Cl, 9.56; N, 11.34; S, 8.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

HI-253; HI253; HI 253; DDE-253; DDE253; DDE 253

IUPAC/Chemical Name

1-(5-Bromopyridin-2-yl)-3-[2-(2-chlorophenyl)ethyl]thiourea

InChi Key

HMOKOLAZSNFEDL-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H13BrClN3S/c15-11-5-6-13(18-9-11)19-14(20)17-8-7-10-3-1-2-4-12(10)16/h1-6,9H,7-8H2,(H2,17,18,19,20)

SMILES Code

S=C(NCCC1=CC=CC=C1Cl)NC2=NC=C(Br)C=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 370.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mao C, Sudbeck EA, Venkatachalam TK, Uckun FM. Structure-based drug design of non-nucleoside inhibitors for wild-type and drug-resistant HIV reverse transcriptase. Biochem Pharmacol. 2000 Nov 1;60(9):1251-65. Review. PubMed PMID: 11008119. 2: D'Cruz OJ, Venkatachalam TK, Uckun FM. Novel thiourea compounds as dual-function microbicides. Biol Reprod. 2000 Jul;63(1):196-205. PubMed PMID: 10859260.