Synonym
Org 7617; Org7617; Org-7617
IUPAC/Chemical Name
Piperidinium, 1-((2beta,3alpha,5alpha,16beta,17beta)-3-(acetyloxy)-17-(1-oxobutoxy)-2-(1-piperidinyl)androstan-16-yl)-1-(2-propenyl)-, bromide
InChi Key
ZJTBGJDGVYKEHQ-HNKPNMMVSA-M
InChi Code
InChI=1S/C38H63N2O4.BrH/c1-6-14-35(42)44-36-33(40(21-7-2)22-12-9-13-23-40)25-31-29-16-15-28-24-34(43-27(3)41)32(39-19-10-8-11-20-39)26-38(28,5)30(29)17-18-37(31,36)4;/h7,28-34,36H,2,6,8-26H2,1,3-5H3;1H/q+1;/p-1/t28-,29+,30-,31-,32-,33-,34-,36-,37-,38-;/m0./s1
SMILES Code
C=CC[N+]1([C@H]2C[C@@]3([H])[C@]4([H])CC[C@@]5([H])C[C@H](OC(C)=O)[C@@H](N6CCCCC6)C[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@H]2OC(CCC)=O)CCCCC1.[Br-]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
691.84
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: van den Broek L, Wierda JM, Proost JH, Hommes FD, Agoston S. Clinical pharmacology of ORG 7617, a short-acting non-depolarizing neuromuscular blocking agent. Eur J Clin Pharmacol. 1994;46(3):225-9. doi: 10.1007/BF00192553. PMID: 7915236.
2: Muir AW, Houston J, Marshall RJ, Bowman WC, Marshall IG. A comparison of the neuromuscular blocking and autonomic effects of two new short-acting muscle relaxants with those of succinylcholine in the anesthetized cat and pig. Anesthesiology. 1989 Mar;70(3):533-40. doi: 10.1097/00000542-198903000-00026. PMID: 2564263.
3: Beaufort TM, Proost JH, Houwertjes MC, Roggeveld J, Wierda JM. The pulmonary first-pass uptake of five nondepolarizing muscle relaxants in the pig. Anesthesiology. 1999 Feb;90(2):477-83. doi: 10.1097/00000542-199902000-00023. PMID: 9952155.
4: Boumén U, Marshall I. Farmakologiia nekotorykh aminosteroidnykh miorelaksantov [Pharmacology of various aminosteroidal muscle relaxants]. Farmakol Toksikol. 1989 May-Jun;52(3):29-33. Russian. PMID: 2571518.
5: Beaufort AM, Wierda JM, Houwertjes MC, Kleef UW, Meijer DK. The isolated heart-lung preparation in the cat. An in situ model to study the role of the lungs in the disposition of drugs. J Pharmacol Toxicol Methods. 1993 Jun;29(3):147-56. doi: 10.1016/1056-8719(93)90066-n. PMID: 8103378.
