LUN42589 | CAS#1848242-58-9 | PI3K/mTOR Inhibitor-2

MedKoo Cat#: 408078 | Name: LUN42589

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LUN42589, also known as PI3K/mTOR Inhibitor-2, is a potent dual pan-PI3K/mTOR inhibitor. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

LUN42589

CAS#1848242-58-9

Theoretical Analysis

MedKoo Cat#: 408078

Name: LUN42589

CAS#: 1848242-58-9

Chemical Formula: C20H13ClF2N4O4S

Exact Mass: 478.0314

Molecular Weight: 478.85

Elemental Analysis: C, 50.17; H, 2.74; Cl, 7.40; F, 7.93; N, 11.70; O, 13.36; S, 6.70

Price and Availability

Size	Price	Availability
500mg	USD 2,850.00	2 Weeks
1g	USD 3,650.00	2 Weeks
2g	USD 5,850.00	2 Weeks

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Related CAS #

No Data

Synonym

PI3K/mTOR Inhibitor-2; LUN42589; LUN-42589; LUN 42589

IUPAC/Chemical Name

N-(5-(3-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-2-methoxypyridin-3-yl)-2,4-difluorobenzenesulfonamide

InChi Key

LQTYGHZRBUVRMR-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H13ClF2N4O4S/c1-31-19-16(26-32(29,30)17-4-3-13(22)7-15(17)23)6-12(8-25-19)11-2-5-18-24-9-14(21)20(28)27(18)10-11/h2-10,26H,1H3

SMILES Code

FC1=CC(F)=C(S(=O)(NC2=CC(C(C=C3)=CN4C3=NC=C(Cl)C4=O)=CN=C2OC)=O)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	Soluble in DMSO	0.0	0.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 478.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Liu W, Ma W, Wang M, Wang Z, Grega SD, Zheng QH, Xu Z. A carbon-11 labeled imidazo[1,2-a]pyridine derivative as a new potential PET probe targeting PI3K/mTOR in cancer. Am J Nucl Med Mol Imaging. 2023 Jun 25;13(3):95-106. PMID: 37457324; PMCID: PMC10349286. 2: Penuel E, Martin GS. Transformation by v-Src: Ras-MAPK and PI3K-mTOR mediate parallel pathways. Mol Biol Cell. 1999 Jun;10(6):1693-703. doi: 10.1091/mbc.10.6.1693. PMID: 10359590; PMCID: PMC25360.