MedKoo Cat#: 555729 | Name: JNJ-64326067

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JNJ-64326067 is a potent and selective binder to aggregated tau with a favorable pharmacokinetic profile and no apparent off-target binding. This was confirmed in rat and monkey positron emission tomography studies using [18F]-JNJ-64326067.

Chemical Structure

JNJ-64326067
JNJ-64326067
CAS#2173357-28-1

Theoretical Analysis

MedKoo Cat#: 555729

Name: JNJ-64326067

CAS#: 2173357-28-1

Chemical Formula: C15H12FN3

Exact Mass: 253.1015

Molecular Weight: 253.28

Elemental Analysis: C, 71.13; H, 4.78; F, 7.50; N, 16.59

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
2173357-41-8 2173357-28-1 2173357-42-9 (18F-labeled)
Synonym
JNJ-64326067; JNJ 64326067; JNJ64326067;
IUPAC/Chemical Name
N-[4-Fluoro-5-methylpyridin-2-yl]isoquinolin-6-amine
InChi Key
YKKAKBCEHOZBEQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H12FN3/c1-10-8-18-15(7-14(10)16)19-13-3-2-12-9-17-5-4-11(12)6-13/h2-9H,1H3,(H,18,19)
SMILES Code
CC1=CN=C(NC2=CC3=C(C=NC=C3)C=C2)C=C1F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
In Alzheimer’s disease, the density and spread of aggregated tau protein track well with neurodegeneration and cognitive decline, making the imaging of aggregated tau a compelling biomarker.

Preparing Stock Solutions

The following data is based on the product molecular weight 253.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Rombouts FJR, Declercq L, Andrés JI, et al. Discovery of N-(4-[18F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer [published correction appears in J Med Chem. 2020 Feb 18;:]. J Med Chem. 2019;62(6):2974–2987. doi:10.1021/acs.jmedchem.8b01759