OT-82 is a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor, exerting its antileukemic action by depleting NAD+ and ATP, inhibiting the NAD+-requiring DNA damage repair enzyme PARP-1, increasing mitochondrial ROS levels and inducing DNA damage, culminating in apoptosis induction.
MedKoo Cat#: 533660
Name: OT-82 HCl
CAS#: OT-82 HCl
Chemical Formula: C26H22ClFN4O
Exact Mass: 424.1699
Molecular Weight: 460.94
Elemental Analysis: C, 67.75; H, 4.81; Cl, 7.69; F, 4.12; N, 12.16; O, 3.47
The following data is based on the product molecular weight 460.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
