Synonym
Synucleozid; NSC 377363; NSC-377363; NSC377363;
IUPAC/Chemical Name
2-(4-((4-Carbamimidoylphenyl)amino)phenyl)-1H-indole-6-carboximidamide
InChi Key
TZRXNWCLKYWDNH-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H20N6/c23-21(24)14-5-9-18(10-6-14)27-17-7-3-13(4-8-17)19-11-15-1-2-16(22(25)26)12-20(15)28-19/h1-12,27-28H,(H3,23,24)(H3,25,26)
SMILES Code
N=C(C1=CC2=C(C=C1)C=C(C3=CC=C(NC4=CC=C(C(N)=N)C=C4)C=C3)N2)N
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
368.44
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Tong Y, Zhang P, Yang X, Liu X, Zhang J, Grudniewska M, Jung I, Abegg D, Liu
J, Childs-Disney JL, Gibaut QMR, Haniff HS, Adibekian A, Mouradian MM, Disney
MD. Decreasing the intrinsically disordered protein α-synuclein levels by
targeting its structured mRNA with a ribonuclease-targeting chimera. Proc Natl
Acad Sci U S A. 2024 Jan 9;121(2):e2306682120. doi: 10.1073/pnas.2306682120.
Epub 2024 Jan 5. PMID: 38181056; PMCID: PMC10786272.
2: Zhang P, Park HJ, Zhang J, Junn E, Andrews RJ, Velagapudi SP, Abegg D, Vishnu
K, Costales MG, Childs-Disney JL, Adibekian A, Moss WN, Mouradian MM, Disney MD.
Translation of the intrinsically disordered protein α-synuclein is inhibited by
a small molecule targeting its structured mRNA. Proc Natl Acad Sci U S A. 2020
Jan 21;117(3):1457-1467. doi: 10.1073/pnas.1905057117. Epub 2020 Jan 3. PMID:
31900363; PMCID: PMC6983430.
