SJF620 is a novel PROTAC, inducing degradation of both wild-type and C481S mutant BTK in immortalized cells and patient-derived B-lymphocytes, showing significantly better pharmacokinetic profile than MT802.
MedKoo Cat#: 533558
Name: SJF620 free base
CAS#: 2376187-16-3 (free base)
Chemical Formula: C41H42N8O8
Exact Mass: 774.3126
Molecular Weight: 774.84
Elemental Analysis: C, 63.56; H, 5.46; N, 14.46; O, 16.52
The following data is based on the product molecular weight 774.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
