Debio-1452-NH3 is a novel potent inhibitor of the enoyl-acyl carrier protein reductase FabI, reducing bacterial burden in mice and rescuing mice from lethal infections with clinical isolates of Acinetobacter baumannii, Klebsiella pneumoniae and E. coli.
MedKoo Cat#: 533453
Name: Debio1452-NH2 HCl
CAS#: 2376749-51-6 (HCl)
Chemical Formula: C22H23ClN4O3
Exact Mass: 426.1459
Molecular Weight: 426.90
Elemental Analysis: C, 61.90; H, 5.43; Cl, 8.30; N, 13.12; O, 11.24
The following data is based on the product molecular weight 426.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
