WR 268668 | CAS#140926-77-8 | anti- parasite agent

MedKoo Cat#: 585424 | Name: WR 268668

Description:

WARNING: This product is for research use only, not for human or veterinary use.

WR 268668 is a bisquinoline against chloroquine-resistant malaria. It is an anti- parasite agent.

Chemical Structure

WR 268668

CAS#140926-77-8

Theoretical Analysis

MedKoo Cat#: 585424

Name: WR 268668

CAS#: 140926-77-8

Chemical Formula: C24H22Cl2N4

Exact Mass: 436.1222

Molecular Weight: 437.37

Elemental Analysis: C, 65.91; H, 5.07; Cl, 16.21; N, 12.81

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

WR 268668; WR268668; WR-268668; Bisquinoline-cxdinh2; Ro 47-7737;

IUPAC/Chemical Name

N1,N2-Bis(7-chloroquinolin-4-yl)cyclohexane-1,2-diamine

InChi Key

LISWOCWHIAZFSB-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H22Cl2N4/c25-15-5-7-17-19(9-11-27-23(17)13-15)29-21-3-1-2-4-22(21)30-20-10-12-28-24-14-16(26)6-8-18(20)24/h5-14,21-22H,1-4H2,(H,27,29)(H,28,30)

SMILES Code

ClC1=CC=C2C(NC3C(NC4=CC=NC5=CC(Cl)=CC=C45)CCCC3)=CC=NC2=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 437.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ridley RG, Matile H, Jaquet C, Dorn A, Hofheinz W, Leupin W, Masciadri R, Theil FP, Richter WF, Girometta MA, Guenzi A, Urwyler H, Gocke E, Potthast JM, Csato M, Thomas A, Peters W. Antimalarial activity of the bisquinoline trans-N1,N2-bis (7-chloroquinolin-4-yl)cyclohexane-1,2-diamine: comparison of two stereoisomers and detailed evaluation of the S,S enantiomer, Ro 47-7737. Antimicrob Agents Chemother. 1997 Mar;41(3):677-86. PubMed PMID: 9056013; PubMed Central PMCID: PMC163771. 2: Vennerstrom JL, Ellis WY, Ager AL Jr, Andersen SL, Gerena L, Milhous WK. Bisquinolines. 1. N,N-bis(7-chloroquinolin-4-yl)alkanediamines with potential against chloroquine-resistant malaria. J Med Chem. 1992 May 29;35(11):2129-34. PubMed PMID: 1597862. 3: Basco LK, Andersen SL, Milhous WK, Le Bras J, Vennerstrom JL. In vitro activity of bisquinoline WR268,668 against African clones and isolates of Plasmodium falciparum. Am J Trop Med Hyg. 1994 Feb;50(2):200-5. PubMed PMID: 8116813.