Vem-bisamide-2 | CAS# | BRAF-V600E degrader.| MedKoo

MedKoo Cat#: 408082 | Name: Vem-bisamide-2

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Vem-bisamide-2 is a BRAF-V600E degrader. Degradation of BRAF-V600E was verified to be dependent on the ubiquitin proteasome system. Chemically Vem-bisamide-2 contains two molecule of Vemurafenib. (Vemurafenib, cat#202271, also known as PLX4032, RG7204 or RO5185426, is an orally bioavailable, ATP-competitive, small-molecule inhibitor of BRAF(V600E)).

Chemical Structure

Vem-bisamide-2

CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 408082

Name: Vem-bisamide-2

CAS#: Unknown

Chemical Formula: C52H50F4N8O9S2

Exact Mass: 1070.3078

Molecular Weight: 1071.13

Elemental Analysis: C, 58.31; H, 4.71; F, 7.09; N, 10.46; O, 13.44; S, 5.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Vem-bisamide-2; Vemurafenib dimer, PLX4032 dimer; PLX-4032 dimer; PLX 4032 dimer; RG7204 dimer; RG-7204 dimer ; RG 7204 dimer ; RO5185426 dimer

IUPAC/Chemical Name

2,2'-oxybis(N-(4-(3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)acetamide)

InChi Key

OQHNUZDJTPNINN-UHFFFAOYSA-N

InChi Code

InChI=1S/C52H50F4N8O9S2/c1-3-17-74(69,70)63-41-15-13-39(53)45(47(41)55)49(67)37-25-61-51-35(37)19-33(23-59-51)31-9-5-29(6-10-31)21-57-43(65)27-73-28-44(66)58-22-30-7-11-32(12-8-30)34-20-36-38(26-62-52(36)60-24-34)50(68)46-40(54)14-16-42(48(46)56)64-75(71,72)18-4-2/h5-16,19-20,23-24,37-38,63-64H,3-4,17-18,21-22,25-28H2,1-2H3,(H,57,65)(H,58,66)(H,59,61)(H,60,62)

SMILES Code

FC1=CC=C(NS(CCC)(=O)=O)C(F)=C1C(C2CNC3=C2C=C(C4=CC=C(CNC(COCC(NCC(C=C5)=CC=C5C6=CC7=C(N=C6)NCC7C(C8=C(F)C(NS(CCC)(=O)=O)=CC=C8F)=O)=O)=O)C=C4)C=N3)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,071.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Discovery of Selective Small Molecule Degraders of BRAF-V600E Xiao-Ran HanLiqun ChenYuanqi WeiWeihua YuYanke ChenChunyan ZhangBingyang JiaoTingting ShiLei SunChao ZhangYang XuMatthew R. LeeYing LuoMichael B. Plewe*Jialiang Wang* Journal of Medicinal Chemistry, Articles ASAP (Article)Subscribed Access Publication Date (Web):March 30, 2020