MedKoo Cat#: 533374 | Name: 118-D-24

Description:

WARNING: This product is for research use only, not for human or veterinary use.

118-D-24 is an inhibitor of HSV-1 replication.

Chemical Structure

118-D-24
118-D-24
CAS#544467-07-4

Theoretical Analysis

MedKoo Cat#: 533374

Name: 118-D-24

CAS#: 544467-07-4

Chemical Formula: C11H9N3O4

Exact Mass: 247.0593

Molecular Weight: 247.21

Elemental Analysis: C, 53.44; H, 3.67; N, 17.00; O, 25.89

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
544467-07-4
Synonym
118-D-24; 118-D 24; 118-D24; 118D-24; 118D 24; 118D24;
IUPAC/Chemical Name
4-[3-(Azidomethyl)phenyl]-2-hydroxy-4-oxo-2-butenoic acid
InChi Key
DWAUHOPROZDIJR-YHYXMXQVSA-N
InChi Code
InChI=1S/C11H9N3O4/c12-14-13-6-7-2-1-3-8(4-7)9(15)5-10(16)11(17)18/h1-5,16H,6H2,(H,17,18)/b10-5-
SMILES Code
O=C(O)/C(O)=C/C(C1=CC=CC(CN=[N+]=[N-])=C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 247.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sanchez AB, Varano GP, de Rozieres CM, Maung R, Catalan IC, Dowling CC, Sejbuk NE, Hoefer MM, Kaul M. Antiretrovirals, Methamphetamine, and HIV-1 Envelope Protein gp120 Compromise Neuronal Energy Homeostasis in Association with Various Degrees of Synaptic and Neuritic Damage. Antimicrob Agents Chemother. 2015 Oct 19;60(1):168-79. doi: 10.1128/AAC.01632-15. PMID: 26482305; PMCID: PMC4704202. 2: Mbemba G, Henry E, Delelis O, Bouger MC, Buckle M, Mouscadet JF, Hazan U, Leh H, Bury-Moné S. Biochemical properties of the xenotropic murine leukemia virus- related virus integrase. Biochimie. 2014 Dec;107 Pt B:300-9. doi: 10.1016/j.biochi.2014.09.019. Epub 2014 Sep 26. PMID: 25260582. 3: Yan Z, Bryant KF, Gregory SM, Angelova M, Dreyfus DH, Zhao XZ, Coen DM, Burke TR Jr, Knipe DM. HIV integrase inhibitors block replication of alpha-, beta-, and gammaherpesviruses. mBio. 2014 Jul 1;5(4):e01318-14. doi: 10.1128/mBio.01318-14. PMID: 24987091; PMCID: PMC4161245. 4: McElrath MJ, Ballweber L, Terker A, Kreger A, Sakchalathorn P, Robinson B, Fialkow M, Lentz G, Hladik F. Ex vivo comparison of microbicide efficacies for preventing HIV-1 genomic integration in intraepithelial vaginal cells. Antimicrob Agents Chemother. 2010 Feb;54(2):763-72. doi: 10.1128/AAC.00891-09. Epub 2009 Nov 30. PMID: 19949052; PMCID: PMC2812173