N‑0920 is a Host-Directed Protease Inhibitor with Picomolar Antiviral Efficacy against Prevalent SARSCoV‑2 Variants. N-0695 exhibited low nanomolar Ki values against three TTSPs associated with respiratory virus entry: TMPRSS2, matriptase, and TMPRSS13. Notably, N-0920 demonstrated exceptional potency in reducing SARS-CoV-2 variants EG.5.1 and JN.1 entry in Calu-3 cells, representing the first in cellulo picomolar inhibitor with EC50 values of 300 and 90 pM, respectively.
MedKoo Cat#: 128716
Name: N‑0920
CAS#: N/A
Chemical Formula: C31H40N8O6S
Exact Mass: 652.2792
Molecular Weight: 652.77
Elemental Analysis: C, 57.04; H, 6.18; N, 17.17; O, 14.71; S, 4.91
The following data is based on the product molecular weight 652.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
