TG11-77 is a novel, Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist. TG11-77 has a Schild KB of 9.7 nM on EP2, a water solubility of 2.5 mM, a brain-to-plasma ratio of 0.4, and a plasma half-life of 2.4 h in mice. TG11-77 are representative second generation EP2 antagonists with improved pharmacodynamic and pharmacokinetic properties.
MedKoo Cat#: 555710
Name: TG11-77 free base
CAS#: 2490544-33-5 (free base)
Chemical Formula: C23H24N6O
Exact Mass: 400.2012
Molecular Weight: 400.49
Elemental Analysis: C, 68.98; H, 6.04; N, 20.99; O, 3.99
The following data is based on the product molecular weight 400.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
