MedKoo Cat#: 585402 | Name: Evoxanthine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Evoxanthine is an alkaloid that has been found in O. renieri and has antimalarial and anticancer activities.

Chemical Structure

Evoxanthine
Evoxanthine
CAS#477-82-7

Theoretical Analysis

MedKoo Cat#: 585402

Name: Evoxanthine

CAS#: 477-82-7

Chemical Formula: C16H13NO4

Exact Mass: 283.0845

Molecular Weight: 283.28

Elemental Analysis: C, 67.84; H, 4.63; N, 4.94; O, 22.59

Price and Availability

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1mg USD 450.00 Back order
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Related CAS #
No Data
Synonym
Evoxanthine; NSC407812; NSC 407812; NSC-407812
IUPAC/Chemical Name
11-methoxy-5-methyl-1,3-dioxolo[4,5-b]acridin-10(5H)-one
InChi Key
ULBVHYNIDQSMFC-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H13NO4/c1-17-10-6-4-3-5-9(10)14(18)13-11(17)7-12-15(16(13)19-2)21-8-20-12/h3-7H,8H2,1-2H3
SMILES Code
O=C1C2=C(C=CC=C2)N(C)C3=CC(OCO4)=C4C(OC)=C13
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 283.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ndongo JT, Mbing JN, Monteillier A, Tala MF, Rütten M, Mombers D, Cuendet M, Pegnyemb DE, Dittrich B, Laatsch H. Carbazole-, Aspidofractinine-, and Aspidocarpamine-Type Alkaloids from Pleiocarpa pycnantha. J Nat Prod. 2018 May 25;81(5):1193-1202. doi: 10.1021/acs.jnatprod.7b00958. Epub 2018 Apr 17. PMID: 29664292. 2: Kenmogne Kouam AD, Kenmogne SB, Songue Lobe J, Ngeufa Happi E, Stammler HG, Kamdem Waffo AF, Sewald N, Wansi JD. A rotameric tryptamide alkaloid from the roots of Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae). Fitoterapia. 2019 Jun;135:9-14. doi: 10.1016/j.fitote.2019.03.028. Epub 2019 Apr 1. PMID: 30946943. 3: Kouam ADK, Bissoue AN, Tcho AT, Happi EN, Waffo AFK, Sewald N, Wansi JD. Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae). Molecules. 2017 Dec 21;23(1):13. doi: 10.3390/molecules23010013. PMID: 29267257; PMCID: PMC5943922. 4: Réthy B, Zupkó I, Minorics R, Hohmann J, Ocsovszki I, Falkay G. Investigation of cytotoxic activity on human cancer cell lines of arborinine and furanoacridones isolated from Ruta graveolens. Planta Med. 2007 Jan;73(1):41-8. doi: 10.1055/s-2006-951747. Epub 2006 Nov 15. PMID: 17109253. 5: Réthy B, Hohmann J, Minorics R, Varga A, Ocsovszki I, Molnár J, Juhász K, Falkay G, Zupkó I. Antitumour properties of acridone alkaloids on a murine lymphoma cell line. Anticancer Res. 2008 Sep-Oct;28(5A):2737-43. PMID: 19035304. 6: PARIS RR, STAMBOULI A. Sur la présence d'un alcalolde identique à l'évoxanthine chez le Teclea grandifolia Engl [The presence of an alkaloid identical to evoxanthine in Teclea grandifolia Engl]. C R Hebd Seances Acad Sci. 1958 Dec 22;247(25):2421-3. French. PMID: 13619123. 7: Kuete V, Fouotsa H, Mbaveng AT, Wiench B, Nkengfack AE, Efferth T. Cytotoxicity of a naturally occurring furoquinoline alkaloid and four acridone alkaloids towards multi-factorial drug-resistant cancer cells. Phytomedicine. 2015 Sep 15;22(10):946-51. doi: 10.1016/j.phymed.2015.07.002. Epub 2015 Jul 17. PMID: 26321744. 8: Koffi Y, Gleye J, Moulis C, Stanislas E. Acridones from Vepris fitoravina and Vepris macrophylla. Planta Med. 1987 Dec;53(6):570-1. doi: 10.1055/s-2006-962815. PMID: 17269101.