JMX0254 HCl | CAS#2375960-04-4

MedKoo Cat#: 533355 | Name: JMX0254 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JMX0254 is a Potent NS4B Inhibitor for the Treatment of Dengue Virus Infection. JMX0254 displayed the most potent and broad inhibitory activities, effective against DENV-1 to -3 with EC50 values of 0.78, 0.16, and 0.035 μM, respectively. JMX0254 exhibited good in vivo pharmacokinetic properties and efficacy in the A129 mouse model.

Chemical Structure

JMX0254 HCl

CAS#JMX0254 HCl

Theoretical Analysis

MedKoo Cat#: 533355

Name: JMX0254 HCl

CAS#: JMX0254 HCl

Chemical Formula: C25H26Cl3N5O2

Exact Mass: 497.1385

Molecular Weight: 534.87

Elemental Analysis: C, 56.14; H, 4.90; Cl, 19.88; N, 13.09; O, 5.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

JMX0254 HCl 2375960-04-4 (free base)

Synonym

JMX0254 HCl; JMX0254 hydrochloride; JMX0254; JMX-0254; JMX 0254;

IUPAC/Chemical Name

(R)-5-Chloro-3'-((S)-1-(4-chlorophenyl)ethyl)-1-isopentyl-3',4'-dihydrospiro[indoline-3,7'-[1,2,3]triazolo[4,5-b]pyridine]-2,5'(6'H)-dione hydrochloride

InChi Key

DFRFSYPFKYDIOV-NCNSGGAMSA-N

InChi Code

InChI=1S/C25H25Cl2N5O2.ClH/c1-14(2)10-11-31-20-9-8-18(27)12-19(20)25(24(31)34)13-21(33)28-23-22(25)29-30-32(23)15(3)16-4-6-17(26)7-5-16;/h4-9,12,14-15H,10-11,13H2,1-3H3,(H,28,33);1H/t15-,25+;/m0./s1

SMILES Code

O=C1N(CCC(C)C)C2=C(C=C(Cl)C=C2)[C@]13C(N=NN4[C@H](C5=CC=C(Cl)C=C5)C)=C4NC(C3)=O.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 534.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.