MedKoo Cat#: 574176 | Name: Pipacycline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pipacycline is a tetracycline antibiotic derivative. It inhibits the formation of penicillinase, the enzyme that inactivates penicillin in bacteria. It decreases oxygen uptake and inhibits growth of penicillin-resistant penicillinase-producing S. aureus.

Chemical Structure

Pipacycline
Pipacycline
CAS#1110-80-1

Theoretical Analysis

MedKoo Cat#: 574176

Name: Pipacycline

CAS#: 1110-80-1

Chemical Formula: C29H38N4O9

Exact Mass: 586.2639

Molecular Weight: 586.64

Elemental Analysis: C, 59.38; H, 6.53; N, 9.55; O, 24.54

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Related CAS #
No Data
Synonym
Mepicycline, Pipacycline
IUPAC/Chemical Name
(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-N-[[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
InChi Key
XATZHCXBMKRRDO-REHNUXHNSA-N
InChi Code
InChI=1S/C29H38N4O9/c1-28(41)15-5-4-6-18(35)19(15)23(36)20-16(28)13-17-22(31(2)3)24(37)21(26(39)29(17,42)25(20)38)27(40)30-14-33-9-7-32(8-10-33)11-12-34/h4-6,16-17,22,34-35,37-38,41-42H,7-14H2,1-3H3,(H,30,40)/t16-,17-,22-,28+,29-/m0/s1
SMILES Code
OC1=C(C(NCN2CCN(CCO)CC2)=O)C([C@@]3(O)C(O)=C4C(C5=C(O)C=CC=C5[C@@](C)(O)[C@@]4([H])C[C@@]3([H])[C@@H]1N(C)C)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
Pipacycline is a tetracycline antibiotic derivative.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 586.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1. Gradnik, B., and Ferrero, E. Mepicycline, a new soluble tetracycline derivative, protects penicillin from penicillinase inactivation. Chemotherapia (Basel) 5, 242-251 (1962).