AZD9898 is a picomolar LTC4S inhibitor (IC50 = 0.28 nM) with high lipophilic ligand efficiency (LLE = 8.5), which displays nanomolar potency in cells (peripheral blood mononuclear cell, IC50,free = 6.2 nM) and good in vivo pharmacodynamics in a calcium ionophore-stimulated rat model after oral dosing (in vivo, IC50,free = 34 nM). AZD9898 is a potential drug candidate for treatment of asthma.
MedKoo Cat#: 533333
Name: AZD9898 HCl
CAS#: AZD9898 HCl
Chemical Formula: C20H20Cl2F3N3O4
Exact Mass: 457.1016
Molecular Weight: 494.29
Elemental Analysis: C, 48.60; H, 4.08; Cl, 14.34; F, 11.53; N, 8.50; O, 12.95
The following data is based on the product molecular weight 494.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
