Synonym
Cyanine5 amine; Cyanine 5 amine; Cy5 amine; Cy5 amine; Cy5-amine; Cy-5-amine;
IUPAC/Chemical Name
1-(6-((6-ammoniohexyl)amino)-6-oxohexyl)-3,3-dimethyl-2-((1E,3E)-5-((E)-1,3,3-trimethylindolin-2-ylidene)penta-1,3-dien-1-yl)-3H-indol-1-ium chloride
InChi Key
ATDODHVIKOGGOS-UHFFFAOYSA-N
InChi Code
InChI=1S/C38H52N4O.2ClH/c1-37(2)30-20-13-15-22-32(30)41(5)34(37)24-10-8-11-25-35-38(3,4)31-21-14-16-23-33(31)42(35)29-19-9-12-26-36(43)40-28-18-7-6-17-27-39;;/h8,10-11,13-16,20-25H,6-7,9,12,17-19,26-29,39H2,1-5H3;2*1H
SMILES Code
CC(C)(/C1=C\C=C\C=C\C2=[N+](C3=CC=CC=C3C2(C)C)CCCCCC(NCCCCCC[NH3+])=O)C4=CC=CC=C4N1C.[Cl-].[Cl-]
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
653.78
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Akhter, D.T.; Simpson, J.D.; Fletcher, N.L.; Houston, Z.H.; Fuchs, A.V.; Bell, C.A.; Thurecht, K.J. Oral Delivery of Multicompartment Nanomedicines for Colorectal Cancer Therapeutics: Combining Loco-Regional Delivery with Cell-Target Specificity. Advanced Therapeutics, in press. doi: 10.1002/adtp.201900171
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3. Sarparanta, M.; Pourat, J.; Carnazza, K.E.; Tang, J.; Paknejad, N.; Reiner, T.; Kostiainen, M.A.; Lewis, J.S. Multimodality labeling strategies for the investigation of nanocrystalline cellulose biodistribution in a mouse model of breast cancer. Nuclear Medicine and Biology, 2020, 80–81, 1–12. doi: 10.1016/j.nucmedbio.2019.11.002
4. Zhou, L.; Wu, Y.; Luo, Y.; Li, H.; Meng, X.; Liu, Cl; Xiang, J.; Zhang, P.; Gong, P.; Cai, L. Mitochondria-localized Self-reporting Small Molecule Decorated Theranostic Agents for Cancer-organelle Transporting and Imaging. ACS Applied Bio Materials, 2019, 2(11), 5164–5173. doi: 10.1021/acsabm.9b00811
