CL2-SN-38 is a cleavable linker-based antibody-drug conjugate (ADC) containing the topoisomerase I inhibitor SN-38 (Cat# 406280) and a maleimidocaproyl linker. CL2-SN-38 has been linked to tumor-selective human monoclonal antibodies, such as anti-CEACAM5 (hMN-14) to target SN-38 to tumor sites and improve its solubility. CL2-SN-38 linked to hMN-14 binds and is cytotoxic to LoVo human colon adenocarcinoma cells. CL2-SN-38 linked to hMN-14 increases survival in a colon carcinoma mouse model of lung metastasis.
MedKoo Cat#: 574147
Name: CL2-SN-38 DCA
CAS#: 1036969-20-6 (free base)
Chemical Formula: C86H110Cl4N12O27
Exact Mass: 1626.7494
Molecular Weight: 1885.68
Elemental Analysis: C, 54.78; H, 5.88; Cl, 7.52; N, 8.91; O, 22.91
The following data is based on the product molecular weight 1,885.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
