Ulotaront, also known as SEP-363856, and SEP-856, is a TAAR1/5-HT1A agonist. Ulotaront interacts with a small, common set of conserved residues within the TAAR1 and 5HT1A ligand-binding domain. Ulotaront is a compound of high solubility, high permeability, and low binding to plasma proteins. Ulotaront metabolism is mediated via both NADPH-dependent and NADPH-independent pathways, with CYP2D6 as the major metabolizing enzyme. Ulotaront is a promising agent for the treatment of schizophrenia with an apparent benign safety profile, which might provide a much-needed new and different treatment option for various domains of schizophrenia.
MedKoo Cat#: 533294
Name: Ulotaront mesylate
CAS#: 2375116-27-9 (mesylate)
Chemical Formula: C10H17NO4S2
Exact Mass: 0.0000
Molecular Weight: 279.37
Elemental Analysis: C, 42.99; H, 6.13; N, 5.01; O, 22.91; S, 22.95
The following data is based on the product molecular weight 279.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
