MS31 is a potent, highly affinity and selective fragment-like methyllysine reader protein spindling 1 (SPIN1) inhibitor. MS31 potently inhibited binding of trimethyllysine-containing peptides to SPIN1, displayed high binding affinity, was highly selective for SPIN1 over other epigenetic readers and writers, directly engaged SPIN1 in cells, and was not toxic to nontumorigenic cells. The crystal structure of the SPIN1-MS31 complex indicated that it selectively binds tudor domain II of SPIN1.
MedKoo Cat#: 533287
Name: MS31 HCl
CAS#: 2748239-18-9 (HCl)
Chemical Formula: C20H30Cl3N3O2
Exact Mass: 341.2103
Molecular Weight: 450.83
Elemental Analysis: C, 53.28; H, 6.71; Cl, 23.59; N, 9.32; O, 7.10
The following data is based on the product molecular weight 450.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
