Decilorubicin | CAS#: 86016-61-7 | anthracycline antibiotic

MedKoo Cat#: 582052 | Name: Decilorubicin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Decilorubicin is a new anthracycline antibiotic.

Chemical Structure

Decilorubicin

CAS#86016-61-7

Theoretical Analysis

MedKoo Cat#: 582052

Name: Decilorubicin

CAS#: 86016-61-7

Chemical Formula: C60H82N4O26

Exact Mass: 1274.5200

Molecular Weight: 1275.32

Elemental Analysis: C, 56.51; H, 6.48; N, 4.39; O, 32.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Decilorubicin

IUPAC/Chemical Name

4-(((2R,3R,4R,6S)-6-(((2R,3R,4S,6R)-6-(((2R,3R,4S,6S)-6-(((2R,3R,4S,5S,6S,11S,13S)-4-(dimethylamino)-11-(((2R,4R,5R,6R)-4-(dimethylamino)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-3,10,13,15-tetrahydroxy-6,13-dimethyl-9,16-dioxo-3,4,5,6,9,11,12,13,14,16-decahydro-2H-2,6-epoxytetraceno[1,2-b]oxocin-5-yl)oxy)-2,4-dimethyl-4-nitrotetrahydro-2H-pyran-3-yl)oxy)-2,4-dimethyl-4-nitrotetrahydro-2H-pyran-3-yl)oxy)-4-methoxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-4-oxobutanoic acid

InChi Key

REJZVZSFWFSPHT-AKTZOFNKSA-N

InChi Code

InChI=1S/C60H82N4O26/c1-24-45(68)31(61(9)10)18-36(80-24)84-33-21-57(5,74)20-29-40(33)48(71)42-43(47(29)70)49(72)41-28(46(42)69)14-15-30-52(41)89-56-50(73)44(62(11)12)55(60(30,8)90-56)88-39-23-59(7,64(77)78)54(27(4)83-39)87-38-22-58(6,63(75)76)53(26(3)82-38)86-37-19-32(79-13)51(25(2)81-37)85-35(67)17-16-34(65)66/h14-15,24-27,31-33,36-39,44-45,50-51,53-56,68,70-71,73-74H,16-23H2,1-13H3,(H,65,66)/t24-,25-,26-,27-,31-,32-,33+,36+,37+,38-,39+,44+,45+,50-,51-,53+,54+,55+,56-,57+,58+,59+,60+/m1/s1

SMILES Code

C1[C@@H](O[C@@H]([C@@H](OC(CCC(O)=O)=O)[C@@H]1OC)C)O[C@@H]1[C@@](C)([N+]([O-])=O)C[C@@H](O[C@@H]2[C@@](C[C@@H](O[C@@H]2C)O[C@@H]2[C@@]3(c4ccc5C(c6c(c(c7C[C@@](C[C@@H](c7c6O)O[C@@H]6O[C@@H]([C@@H]([C@@H](C6)N(C)C)O)C)(O)C)O)C(c5c4O[C@@H]([C@@H]([C@@H]2N(C)C)O)O3)=O)=O)C)(C)[N+]([O-])=O)O[C@@H]1C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,275.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Aoki M, Shirai H, Nakayama N, Itezono Y, Mori M, Satoh T, Ohshima S, Watanabe J, Yokose K, Seto H. Structural studies on avidinorubicin, a novel anthracycline with platelet aggregation inhibitory activity. J Antibiot (Tokyo). 1991 Jun;44(6):635-45. PubMed PMID: 2071489. 2: Izawa T, Nishimura Y, Kondo S. 3-Amino-5-C-phenyl-D-altrofuranose and 3-amino-5-C-[3-carboxy-4-(carboxymethyl)-2-oxo-3-cyclohexen-1-yl] -D-altrofuranose, possible intermediates for synthesis of of the anthracycline antibiotic decilorubicin. Carbohydr Res. 1991 Apr 2;211(1):137-46. PubMed PMID: 1773426. 3: Nishimura Y, Ishii K, Kondo S. The absolute configuration of decilonitrose, a sugar component of decilorubicin, is undoubtedly 2,3,6-trideoxy-3-C-methyl-3-nitro-L-ribo-hexopyranose. J Antibiot (Tokyo). 1990 Jan;43(1):54-61. PubMed PMID: 2307630. 4: Kind R, Hütter K, Zeeck A, Schmidt-Bäse K, Egert E. Viriplanin A, a new anthracycline antibiotic of the nogalamycin group. II. The structure of a novel hydroxyamino sugar from reduced viriplanin A. J Antibiot (Tokyo). 1989 Jan;42(1):7-13. PubMed PMID: 2921229. 5: Fox KR. Footprinting studies on the interactions of nogalamycin, arugomycin, decilorubicin and viriplanin with DNA. Anticancer Drug Des. 1988 Dec;3(3):157-68. PubMed PMID: 3207463. 6: Hütter K, Baader E, Frobel K, Zeeck A, Bauer K, Gau W, Kurz J, Schröder T, Wünsche C, Karl W, et al. Viriplanin A, a new anthracycline antibiotic of the nogalamycin group. I. Isolation, characterization, degradation reactions and biological properties. J Antibiot (Tokyo). 1986 Sep;39(9):1193-204. PubMed PMID: 3023268. 7: Tatsuta K. [New anthracycline antibiotics and derivatives]. Gan To Kagaku Ryoho. 1984 Dec;11(12 Pt 2):2640-52. Japanese. PubMed PMID: 6594977. 8: Ishii K, Nishimura Y, Naganawa H, Kondo S, Umezawa H. The structure of decilorubicin. J Antibiot (Tokyo). 1984 Apr;37(4):344-53. PubMed PMID: 6704208. 9: Ishii K, Nishimura Y, Kondo S, Umezawa H. Decilonitrose and 4-O-succinyl-L-diginose, sugar components of decilorubicin. J Antibiot (Tokyo). 1983 Apr;36(4):454-6. PubMed PMID: 6853376. 10: Ishii K, Kondo S, Nishimura Y, Hamada M, Takeuchi T, Umezawa H. Decilorubicin, a new anthracycline antibiotic. J Antibiot (Tokyo). 1983 Apr;36(4):451-3. PubMed PMID: 6853375.