Related CAS #
1329-04-0 (O-methylustin)
Synonym
Methylustin; Nidulin
IUPAC/Chemical Name
1-[(E)-but-2-en-2-yl]-2,8,10-trichloro-9-hydroxy-3-methoxy-4,7-dimethylbenzo[b][1,4]benzodioxepin-6-one
InChi Key
RYPBEWJCFCTVSG-SOFGYWHQSA-N
InChi Code
InChI=1S/C20H20Cl3O5/c1-6-8(2)12-11-7-28(23)20-16(25)13(21)9(3)15(24)19(20)27-17(11)10(4)18(26-5)14(12)22/h6,9,25H,7H2,1-5H3/b8-6+
SMILES Code
O=C1C(C)C(Cl)=C(O)C2=C1OC3=C(C)C(OC)=C(Cl)C(/C(C)=C/C)=C3CO2Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Nidulin is a depsidone originally isolated from A. nidulans that has antibacterial and antifungal properties.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
446.73
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Dean, F.M., Roberston, A., Roberts, J.C., et al. Nidulin and “Ustin”: Two chlorine-containing metabolic products of Aspergillus nidulans. Nature 172(4372), 344 (1953).
2. Zhang, Y., Mu, J., Feng, Y., et al. Four chlorinated depsidones from a seaweed-derived strain of Aspergillus unguis and their new biological activities. Nat. Prod. Res. 28(7), 503-506 (2014).
3. Sureram, S., Wiyakrutta, S., Ngamrojanavanich, N., et al. Depsidones, aromatase inhibitors and radical scavenging agents from the marine-derived fungus Aspergillus unguis CRI282-03. Planta Med. 78(6), 582-588 (2012).
