LUN80466, also known as ACK1 inhibitor and B19, is a ACK inhibitor (ACK1, 15 nM Kd in Ambit binding assay, 35.4 nM IC50 in Invitrogen kinase assay). B19 inhibited kinase activity of ACK1 by monitoring EGF-induced autophosphorylation in HEK293 cell at 2 μM. B19 completely inhibited lung cancer cell A549 growth at 10 μM. LUN80466 was first reported in Chem Biol. 2011 Jul 29;18(7):868-79. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
MedKoo Cat#: 555696
Name: LUN80466
CAS#: 1234480-46-6 (free base)
Chemical Formula: C24H27N7O2
Exact Mass: 445.2226
Molecular Weight: 445.53
Elemental Analysis: C, 64.70; H, 6.11; N, 22.01; O, 7.18
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| Soluble in DMSO | 0.0 | 0.00 |
The following data is based on the product molecular weight 445.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
