MedKoo Cat#: 555694 | Name: PSB-1584

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PSB-1584 is a Potent Agonist of the Orphan G Protein-Coupled Receptor 84 (GPR84). GPR84, a Gi protein-coupled receptor that is activated by medium-chain (hydroxy)fatty acids, appears to play an important role in inflammation, immunity, and cancer.

Chemical Structure

PSB-1584
PSB-1584
CAS#72255-76-6 (free base)

Theoretical Analysis

MedKoo Cat#: 555694

Name: PSB-1584

CAS#: 72255-76-6 (free base)

Chemical Formula: C10H17N3O2

Exact Mass: 211.1321

Molecular Weight: 211.27

Elemental Analysis: C, 56.85; H, 8.11; N, 19.89; O, 15.15

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
PSB-1584; PSB 1584; PSB1584;
IUPAC/Chemical Name
6-Hexylamino-2,4(1H,3H)-pyrimidinedione
InChi Key
SDXQSUJXSHUIBQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H17N3O2/c1-2-3-4-5-6-11-8-7-9(14)13-10(15)12-8/h7H,2-6H2,1H3,(H3,11,12,13,14,15)
SMILES Code
O=C1NC(C=C(NCCCCCC)N1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 211.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Köse M, Pillaiyar T, Namasivayam V, De Filippo E, Sylvester K, Ulven T, von Kügelgen I, Müller CE. An Agonist Radioligand for the Proinflammatory Lipid-Activated G Protein-Coupled Receptor GPR84 Providing Structural Insights. J Med Chem. 2019 Nov 27. doi: 10.1021/acs.jmedchem.9b01339. [Epub ahead of print] PubMed PMID: 31721581. 2: Pillaiyar T, Köse M, Namasivayam V, Sylvester K, Borges G, Thimm D, von Kügelgen I, Müller CE. 6-(Ar)Alkylamino-Substituted Uracil Derivatives: Lipid Mimetics with Potent Activity at the Orphan G Protein-Coupled Receptor 84 (GPR84). ACS Omega. 2018 Mar 31;3(3):3365-3383. doi: 10.1021/acsomega.7b02092. Epub 2018 Mar 20. PubMed PMID: 30023867; PubMed Central PMCID: PMC6044507.