Synonym
UR 8225; UR8225; UR-8225
IUPAC/Chemical Name
2-Naphthalenecarbonitrile, 5,6-dihydro-6,6-dimethyl-5-oxo-8-(2-oxo-1(2H)-pyridinyl)-
InChi Key
PJCGOKFHROWGBX-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H14N2O2/c1-18(2)10-15(20-8-4-3-5-16(20)21)14-9-12(11-19)6-7-13(14)17(18)22/h3-10H,1-2H3
SMILES Code
N#CC(C=C1C(N2C=CC=CC2=O)=CC3(C)C)=CC=C1C3=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
290.32
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Perez-Vizcaino F, Casis O, Rodriguez R, Gomez LA, Garcia Rafanell J, Tamargo J. Effects of the novel potassium channel opener, UR-8225, on contractile responses in rat isolated smooth muscle. Br J Pharmacol. 1993 Nov;110(3):1165-71. PubMed PMID: 8298804; PubMed Central PMCID: PMC2175824.
2: Tamargo J, Pérez O, Delpón E, García-Rafanell J, Gómez L, Cavalcanti F. Cardiovascular effects of the novel potassium channel opener UR-8225. J Cardiovasc Pharmacol. 1995 Aug;26(2):295-305. PubMed PMID: 7475055.
3: Nieto C, Ramis J, Conte L, Fernández JM, Forn J. On-line fully automated solid-phase extraction-liquid chromatography analysis of 1,2-dihydro-4-(1,2-dihydro-2-oxo-1-pyridyl)-2,2-dimethyl-1-oxonaphthale ne-6- carbonitrile (UR-8225), a new potassium channel opener, in plasma samples. J Chromatogr B Biomed Appl. 1994 Nov 18;661(2):319-25. PubMed PMID: 7894673.
4: Almansa C, Gómez LA, Cavalcanti FL, Rodríguez R, Carceller E, Bartrolí J, García-Rafanell J, Forn J. 2,2-Dialkylnaphthalen-1-ones as new potassium channel activators. J Med Chem. 1993 Jul 23;36(15):2121-33. PubMed PMID: 8340916.
