UR 8225 | CAS#149455-36-7 | activator

MedKoo Cat#: 585303 | Name: UR 8225

Description:

WARNING: This product is for research use only, not for human or veterinary use.

UR 8225 is a potassium channel activator with cardiovascular activity.

Chemical Structure

UR 8225

CAS#149455-36-7

Theoretical Analysis

MedKoo Cat#: 585303

Name: UR 8225

CAS#: 149455-36-7

Chemical Formula: C18H14N2O2

Exact Mass: 290.1055

Molecular Weight: 290.32

Elemental Analysis: C, 74.47; H, 4.86; N, 9.65; O, 11.02

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

UR 8225; UR8225; UR-8225

IUPAC/Chemical Name

2-Naphthalenecarbonitrile, 5,6-dihydro-6,6-dimethyl-5-oxo-8-(2-oxo-1(2H)-pyridinyl)-

InChi Key

PJCGOKFHROWGBX-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H14N2O2/c1-18(2)10-15(20-8-4-3-5-16(20)21)14-9-12(11-19)6-7-13(14)17(18)22/h3-10H,1-2H3

SMILES Code

N#CC(C=C1C(N2C=CC=CC2=O)=CC3(C)C)=CC=C1C3=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 290.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Perez-Vizcaino F, Casis O, Rodriguez R, Gomez LA, Garcia Rafanell J, Tamargo J. Effects of the novel potassium channel opener, UR-8225, on contractile responses in rat isolated smooth muscle. Br J Pharmacol. 1993 Nov;110(3):1165-71. PubMed PMID: 8298804; PubMed Central PMCID: PMC2175824. 2: Tamargo J, Pérez O, Delpón E, García-Rafanell J, Gómez L, Cavalcanti F. Cardiovascular effects of the novel potassium channel opener UR-8225. J Cardiovasc Pharmacol. 1995 Aug;26(2):295-305. PubMed PMID: 7475055. 3: Nieto C, Ramis J, Conte L, Fernández JM, Forn J. On-line fully automated solid-phase extraction-liquid chromatography analysis of 1,2-dihydro-4-(1,2-dihydro-2-oxo-1-pyridyl)-2,2-dimethyl-1-oxonaphthale ne-6- carbonitrile (UR-8225), a new potassium channel opener, in plasma samples. J Chromatogr B Biomed Appl. 1994 Nov 18;661(2):319-25. PubMed PMID: 7894673. 4: Almansa C, Gómez LA, Cavalcanti FL, Rodríguez R, Carceller E, Bartrolí J, García-Rafanell J, Forn J. 2,2-Dialkylnaphthalen-1-ones as new potassium channel activators. J Med Chem. 1993 Jul 23;36(15):2121-33. PubMed PMID: 8340916.