U-90042 is a nonbenzodiazepine sedative and hypnotic compound that selectively modulates GABAₐ receptors, primarily targeting the α₁, α₃, and α₆ subtypes with Ki values of 7.8 nM, 9.5 nM, and 11.0 nM, respectively. It enhances GABA-induced chloride currents in α₆β₂γ₂ receptors, leading to sedation and ataxia, and prolongs sleep duration in mice, rats, and monkeys. Unlike traditional benzodiazepine hypnotics, U-90042 does not induce amnesia and can antagonize the amnestic effects of diazepam, indicating a distinct interaction profile with GABAₐ receptor subtypes.
MedKoo Cat#: 585292
Name: U 90042
CAS#: 134516-99-7
Chemical Formula: C17H13ClN6O
Exact Mass: 352.0839
Molecular Weight: 352.78
Elemental Analysis: C, 57.88; H, 3.71; Cl, 10.05; N, 23.82; O, 4.54
The following data is based on the product molecular weight 352.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
