JH-XII-03-02 is a PROTAC targeting LRRK2. JH-XII-03-0 displayed high potency and remarkable selectivity for LRKK2 when assessed in a of 468 panel kinases and serves the dual purpose of eliminating both the kinase activity as well as the scaffolding function of LRRK2.
MedKoo Cat#: 124991
Name: JH-XII-03-02
CAS#: N/A
Chemical Formula: C24H31N3O9
Exact Mass: 505.2100
Molecular Weight: 505.52
Elemental Analysis: C, 57.02; H, 6.18; N, 8.31; O, 28.48
The following data is based on the product molecular weight 505.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
