Norlidocaine is an active metabolite of lidocaine formed via N-deethylation of lidocaine by the hepatic cytochrome P450 (CYP) isoform CYP3A4. Topical administration reduces thrombus formation in microvascular injury. Plasma levels of Norlidocaine following lidocaine administration have been used to monitor declining liver function in patients with cirrhosis.
MedKoo Cat#: 574108
Name: Norlidocaine HCl
CAS#: 7729-94-4 (HCl)
Chemical Formula: C12H19ClN2O
Exact Mass: 242.1186
Molecular Weight: 242.75
Elemental Analysis: C, 59.38; H, 7.89; Cl, 14.60; N, 11.54; O, 6.59
| Solvent | mg/mL | mM | comments | |
|---|---|---|---|---|
| Solubility | ||||
| DMF | 1.0 | 4.12 | ||
| DMSO | 5.0 | 20.60 | ||
| Ethanol | 2.0 | 8.24 | ||
| PBS (pH 7.2) | 5.0 | 20.60 |
The following data is based on the product molecular weight 242.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
