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MedKoo Cat#: 585276 | Name: Triredisol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Triredisol is an active form of vitamin B12, which is used to treat anemia as well as nerve damage with numbness, tingling, pain in various neurological disorders.

Chemical Structure

Triredisol
Triredisol
CAS#76773-81-4

Theoretical Analysis

MedKoo Cat#: 585276

Name: Triredisol

CAS#: 76773-81-4

Chemical Formula: C12H17ClN4OS; C8H11NO3; CCoN+; C62H88N13O14P2-

Exact Mass: 300.0812

Molecular Weight: 300.81

Elemental Analysis: C, 47.92; H, 5.70; Cl, 11.79; N, 18.63; O, 5.32; S, 10.66; C, 56.80; H, 6.55; N, 8.28; O, 28.37; C, 14.14; Co, 69.37; N, 16.49; C, 58.62; H, 6.98; N, 14.33; O, 17.63; P, 2.44

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Triredisol; Triredisol-H; Methylcobalamin
IUPAC/Chemical Name
Vitamin B12, mixt. with 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazolium chloride and 5-hydroxy-6-methyl-3,4-pyridinedimethanol
InChi Key
ZREOCNMDHNHHDJ-TXAVSEIZSA-K
InChi Code
InChI=1S/C62H90N13O14P.C12H17N4OS.C8H11NO3.CN.ClH.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;1-5-8(12)7(4-11)6(3-10)2-9-5;1-2;;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);2,10-12H,3-4H2,1H3;;1H;/q;+1;;;;+1/p-3/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;;;;;/m1...../s1
SMILES Code
C/C(C1=N/C([C@@H](CCC(N)=O)[C@]1(C)CC(N)=O)=C\C2=N/C([C@@H](CCC(N)=O)C2(C)C)=C3C)=C4[C@@H](CCC(N)=O)[C@@](CC(N)=O)(C)[C@@]([C@@]5([H])[C@H](CC(N)=O)[C@@](C)(CCC(NC[C@@H](C)O[P@](O[C@]6([H])[C@](CO)([H])O[C@@](N7C(C=C(C)C(C)=C8)=C8N=C7)([H])[C@]6([H])O)([O-])=O)=O)C/3=N5)(C)[N-]\4.[Co+]C#N.OCC9=C(CO)C(O)=C(C)N=C9.CC%10=C(CCO)SC=[N+]%10CC%11=CN=C(C)N=C%11N.[Cl-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 300.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang M, Han W, Hu S, Xu H. Methylcobalamin: a potential vitamin of pain killer. Neural Plast. 2013;2013:424651. doi: 10.1155/2013/424651. Epub 2013 Dec 26. Review. PubMed PMID: 24455309; PubMed Central PMCID: PMC3888748. 2: Han X, Wang L, Shi H, Zheng G, He J, Wu W, Shi J, Wei G, Zheng W, Sun J, Huang H, Cai Z. Acupuncture combined with methylcobalamin for the treatment of chemotherapy-induced peripheral neuropathy in patients with multiple myeloma. BMC Cancer. 2017 Jan 9;17(1):40. doi: 10.1186/s12885-016-3037-z. PubMed PMID: 28068938; PubMed Central PMCID: PMC5223334. 3: Ito S, Izumi Y, Niidome T, Ono Y. Methylcobalamin prevents mutant superoxide dismutase-1-induced motor neuron death in vitro. Neuroreport. 2017 Jan 18;28(2):101-107. doi: 10.1097/WNR.0000000000000716. PubMed PMID: 27922548. 4: Verma D, Chandra J, Kumar P, Shukla S, Sengupta S. Efficacy of oral methylcobalamin in treatment of vitamin B12 deficiency anemia in children. Pediatr Blood Cancer. 2017 Dec;64(12). doi: 10.1002/pbc.26698. Epub 2017 Jul 1. PubMed PMID: 28667789. 5: Ikeda K, Iwasaki Y, Kaji R. Neuroprotective effect of ultra-high dose methylcobalamin in wobbler mouse model of amyotrophic lateral sclerosis. J Neurol Sci. 2015 Jul 15;354(1-2):70-4. doi: 10.1016/j.jns.2015.04.052. Epub 2015 May 8. PubMed PMID: 25982504. 6: Li S, Chen X, Li Q, Du J, Liu Z, Peng Y, Xu M, Li Q, Lei M, Wang C, Zheng S, Zhang X, Yu H, Shi J, Tao S, Feng P, Tian H. Effects of acetyl-L-carnitine and methylcobalamin for diabetic peripheral neuropathy: A multicenter, randomized, double-blind, controlled trial. J Diabetes Investig. 2016 Sep;7(5):777-85. doi: 10.1111/jdi.12493. Epub 2016 Mar 28. PubMed PMID: 27180954; PubMed Central PMCID: PMC5009142. 7: Metin SK, Meydan B, Evman S, Dogruyol T, Baysungur V. The Effect of Pregabalin and Methylcobalamin Combination on the Chronic Postthoracotomy Pain Syndrome. Ann Thorac Surg. 2017 Apr;103(4):1109-1113. doi: 10.1016/j.athoracsur.2016.09.031. Epub 2016 Dec 1. PubMed PMID: 27916242. 8: Jiang DQ, Zhao SH, Li MX, Jiang LL, Wang Y, Wang Y. Prostaglandin E1 plus methylcobalamin combination therapy versus prostaglandin E1 monotherapy for patients with diabetic peripheral neuropathy: A meta-analysis of randomized controlled trials. Medicine (Baltimore). 2018 Nov;97(44):e13020. doi: 10.1097/MD.0000000000013020. Review. PubMed PMID: 30383660; PubMed Central PMCID: PMC6221723. 9: Xu J, Wang W, Zhong XX, Feng Y, Wei X, Liu XG. EXPRESS: Methylcobalamin ameliorates neuropathic pain induced by vincristine in rats: Effect on loss of peripheral nerve fibers and imbalance of cytokines in the spinal dorsal horn. Mol Pain. 2016 Jun 15;12. pii: 1744806916657089. doi: 10.1177/1744806916657089. Print 2016. PubMed PMID: 27306413; PubMed Central PMCID: PMC4956006. 10: Han Y, Wang M, Shen J, Zhang Z, Zhao M, Huang J, Chen Y, Chen Z, Hu Y, Wang Y. Differential efficacy of methylcobalamin and alpha-lipoic acid treatment on symptoms of diabetic peripheral neuropathy. Minerva Endocrinol. 2018 Mar;43(1):11-18. doi: 10.23736/S0391-1977.16.02505-0. Epub 2016 Nov 30. PubMed PMID: 27901334. 11: Jiang DQ, Xu LC, Jiang LL, Li MX, Wang Y. Fasudil combined with methylcobalamin or lipoic acid can improve the nerve conduction velocity in patients with diabetic peripheral neuropathy: A meta-analysis. Medicine (Baltimore). 2018 Jul;97(27):e11390. doi: 10.1097/MD.0000000000011390. Review. PubMed PMID: 29979431; PubMed Central PMCID: PMC6076121. 12: ALSUntangled Group. ALSUntangled No. 30: methylcobalamin. Amyotroph Lateral Scler Frontotemporal Degener. 2015;16(7-8):536-9. doi: 10.3109/21678421.2015.1070574. Epub 2015 Jul 23. Review. PubMed PMID: 26203660. 13: Yao H, Feng J, Zheng Q, Wei Y, Wang S, Feng W. The effects of gliclazide, methylcobalamin, and gliclazide+methylcobalamin combination therapy on diabetic peripheral neuropathy in rats. Life Sci. 2016 Sep 15;161:60-8. doi: 10.1016/j.lfs.2016.07.019. Epub 2016 Aug 3. PubMed PMID: 27496624. 14: Trippe BS, Barrentine LW, Curole MV, Tipa E. Nutritional management of patients with diabetic peripheral neuropathy with L-methylfolate-methylcobalamin-pyridoxal-5-phosphate: results of a real-world patient experience trial. Curr Med Res Opin. 2016;32(2):219-27. doi: 10.1185/03007995.2015.1103215. Epub 2015 Dec 8. PubMed PMID: 26439233. 15: Vijayakumar TM, Pavitra K, Muthunarayanan L. Comparative assessment of methylcobalamin and ascorbic acid on cognitive function in post-menopausal women - A randomized, double-blind trial. Contemp Clin Trials Commun. 2017 Oct 16;8:175-180. doi: 10.1016/j.conctc.2017.10.006. eCollection 2017 Dec. PubMed PMID: 29696207; PubMed Central PMCID: PMC5898509. 16: Zhang YF, Ning G. Mecobalamin. Expert Opin Investig Drugs. 2008 Jun;17(6):953-64. doi: 10.1517/13543784.17.6.953 . Review. PubMed PMID: 18491996. 17: Liao WC, Wang YJ, Huang MC, Tseng GF. Methylcobalamin facilitates collateral sprouting of donor axons and innervation of recipient muscle in end-to-side neurorrhaphy in rats. PLoS One. 2013 Sep 30;8(9):e76302. doi: 10.1371/journal.pone.0076302. eCollection 2013. PubMed PMID: 24098787; PubMed Central PMCID: PMC3786991. 18: Thakkar K, Billa G. Treatment of vitamin B12 deficiency-methylcobalamine? Cyancobalamine? Hydroxocobalamin?-clearing the confusion. Eur J Clin Nutr. 2015 Jan;69(1):1-2. doi: 10.1038/ejcn.2014.165. Epub 2014 Aug 13. PubMed PMID: 25117994. 19: Sato S, Kudo F, Kim SY, Kuzuyama T, Eguchi T. Methylcobalamin-Dependent Radical SAM C-Methyltransferase Fom3 Recognizes Cytidylyl-2-hydroxyethylphosphonate and Catalyzes the Nonstereoselective C-Methylation in Fosfomycin Biosynthesis. Biochemistry. 2017 Jul 18;56(28):3519-3522. doi: 10.1021/acs.biochem.7b00472. Epub 2017 Jul 7. PubMed PMID: 28678474. 20: Andruniów T, Lodowski P, Garabato BD, Jaworska M, Kozlowski PM. The role of spin-orbit coupling in the photolysis of methylcobalamin. J Chem Phys. 2016 Mar 28;144(12):124305. doi: 10.1063/1.4943184. PubMed PMID: 27036446.