ONO-TR-772 is a potent (TREK-1 IC50 = 15 nM),selective (>10 μM versus other K2P channels except TREK-2), and CNS penetrant (rat Kp = 0.98) TREK inhibitor. ONO-TR-772 (VU6018042) demonstrated robust efficacy in an MK-801 challengeNOR paradigm, with an MED of 10 mg/kg.
MedKoo Cat#: 128844
Name: ONO-TR-772
CAS#: N/A
Chemical Formula: C26H23ClFN3O3
Exact Mass: 479.1412
Molecular Weight: 479.94
Elemental Analysis: C, 65.07; H, 4.83; Cl, 7.39; F, 3.96; N, 8.76; O, 10.00
The following data is based on the product molecular weight 479.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
