DCZ3112 is a novel Hsp90 inhibitor. DCZ3112 directly bound to the N-terminal domain of Hsp90 and inhibited Hsp90-Cdc37 interaction without inhibiting ATPase activity. DCZ3112 inhibited the proliferation predominantly in HER2-positive breast cancer cells, including those resistant to the classical Hsp90 inhibitor geldanamycin, which mainly targets ATPase.
MedKoo Cat#: 593133
Name: DCZ3112
CAS#: 2556837-25-1
Chemical Formula: C15H14ClF3N8
Exact Mass: 398.0982
Molecular Weight: 398.78
Elemental Analysis: C, 45.18; H, 3.54; Cl, 8.89; F, 14.29; N, 28.10
The following data is based on the product molecular weight 398.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
