MedKoo Cat#: 575465 | Name: FK-448 methanesulfonate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FK-448 methanesulfonate is a chymotrypsin inhibitor that has been shown to affect intestinal absorption of insulin in rats and dogs .

Chemical Structure

FK-448 methanesulfonate
FK-448 methanesulfonate
CAS#85858-77-1

Theoretical Analysis

MedKoo Cat#: 575465

Name: FK-448 methanesulfonate

CAS#: 85858-77-1

Chemical Formula: C26H34N2O6S

Exact Mass: 502.2138

Molecular Weight: 502.63

Elemental Analysis: C, 62.13; H, 6.82; N, 5.57; O, 19.10; S, 6.38

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
89703-10-6
Synonym
FK 448 methanesulfonate; FK448 methanesulfonate; FK-448 methanesulfonate
IUPAC/Chemical Name
1-Naphthalenecarboxylic acid, 1,2,3,4-tetrahydro-, 4-((4-(1-methylethyl)-1-piperazinyl)carbonyl)phenyl ester, methanesulfonate
InChi Key
BVNMUHYZMQDZPJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H30N2O3.CH4O3S/c1-18(2)26-14-16-27(17-15-26)24(28)20-10-12-21(13-11-20)30-25(29)23-9-5-7-19-6-3-4-8-22(19)23;1-5(2,3)4/h3-4,6,8,10-13,18,23H,5,7,9,14-17H2,1-2H3;1H3,(H,2,3,4)
SMILES Code
CC(C)N1CCN(CC1)C(=O)c2ccc(OC(=O)C3CCCc4ccccc34)cc2.CS(=O)(=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 502.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Fujii S, Yokoyama T, Ikegaya K, Sato F, Yokoo N. Promoting effect of the new chymotrypsin inhibitor FK-448 on the intestinal absorption of insulin in rats and dogs. J Pharm Pharmacol. 1985 Aug;37(8):545-9. doi: 10.1111/j.2042-7158.1985.tb03064.x. PMID: 2864414. 2. Bernkop-Schnürch A. The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins. J Control Release. 1998 Mar 2;52(1-2):1-16. doi: 10.1016/s0168-3659(97)00204-6. PMID: 9685931.