MedKoo Cat#: 574078 | Name: AMG-Tie2-1
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) and VEGF receptor 2 (VEGFR2).

Chemical Structure

AMG-Tie2-1
AMG-Tie2-1
CAS#870223-96-4

Theoretical Analysis

MedKoo Cat#: 574078

Name: AMG-Tie2-1

CAS#: 870223-96-4

Chemical Formula: C25H20F3N5O2

Exact Mass: 479.1569

Molecular Weight: 479.46

Elemental Analysis: C, 62.63; H, 4.20; F, 11.89; N, 14.61; O, 6.67

Price and Availability

Size Price Availability Quantity
25mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
100mg USD 1,250.00 2 Weeks
200mg USD 1,950.00 2 Weeks
1g USD 4,650.00 2 Weeks
2g USD 6,650.00 2 Weeks
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Related CAS #
Synonym
AMG-Tie2-1
IUPAC/Chemical Name
4-methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]-benzamide
InChi Key
ZVIWALRWYYSHSU-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H20F3N5O2/c1-15-8-9-16(22(34)32-18-6-3-5-17(14-18)25(26,27)28)13-21(15)35-23-19(7-4-11-30-23)20-10-12-31-24(29-2)33-20/h3-14H,1-2H3,(H,32,34)(H,29,31,33)
SMILES Code
FC(F)(F)C1=CC=CC(NC(C2=CC=C(C)C(OC3=NC=CC=C3C4=NC(NC)=NC=C4)=C2)=O)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 479.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Hodous, B.L., Geuns-Meyer, S.D., Hughes, P.E., et al. Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor. J. Med. Chem. 50(4), 611-626 (2007).