BI-9321 is a novel potent and selective antagonist of the PWWP1 domain of NSD3. BI-9321 targets the methyl-lysine binding site of the PWWP1 domain with sub-micromolar in vitro activity and cellular target engagement at 1 µM. As a single agent, BI-9321 downregulates Myc messenger RNA expression and reduces proliferation in MOLM-13 cells. This first-in-class chemical probe BI-9321, together with the negative control BI-9466, will greatly facilitate the elucidation of the underexplored biological function of PWWP domains.
MedKoo Cat#: 533144
Name: BI-9321 HCl
CAS#: 387510-87-2 (HCl)
Chemical Formula: C22H24Cl3FN4
Exact Mass: 468.1051
Molecular Weight: 469.81
Elemental Analysis: C, 56.24; H, 5.15; Cl, 22.64; F, 4.04; N, 11.93
The following data is based on the product molecular weight 469.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
