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MedKoo Cat#: 585242 | Name: Tfc 612

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tfc 612 prevents decrease in motor nerve conduction velocity in streptozocin-diabetic rats and is a derivative of thiaprostaglandin E1.

Chemical Structure

Tfc 612
CAS#83058-69-9

Theoretical Analysis

MedKoo Cat#: 585242

Name: Tfc 612

CAS#: 83058-69-9

Chemical Formula: C22H38O5S

Exact Mass: 414.2440

Molecular Weight: 414.60

Elemental Analysis: C, 63.73; H, 9.24; O, 19.29; S, 7.73

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Tfc 612; Tfc-612; Tfc612
IUPAC/Chemical Name
Hexanoic acid, 6-((3-hydroxy-2-(3-hydroxy-5-methyl-1-nonenyl)-5-oxocyclopentyl)thio)-, methyl ester, (1R-(1alpha,2beta(1E,3S*,5R*),3alpha))-
InChi Key
KMYUINCCFSNYPC-VPTZPLTNSA-N
InChi Code
InChI=1S/C22H38O5S/c1-4-5-9-16(2)14-17(23)11-12-18-19(24)15-20(25)22(18)28-13-8-6-7-10-21(26)27-3/h11-12,16-19,22-24H,4-10,13-15H2,1-3H3/b12-11+/t16-,17?,18+,19-,22-/m1/s1
SMILES Code
O=C(OC)CCCCCS[C@@H]1[C@@H](/C=C/C(O)C[C@H](C)CCCC)[C@H](O)CC1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 414.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yasuda H, Sonobe M, Yamashita M, Terada M, Hatanaka I, Huitian Z, Shigeta Y. Effect of prostaglandin E1 analogue TFC 612 on diabetic neuropathy in streptozocin-induced diabetic rats. Comparison with aldose reductase inhibitor ONO 2235. Diabetes. 1989 Jul;38(7):832-8. PubMed PMID: 2525492. 2: Motoyama Y, Sakata Y, Seki J, Asada T, Namikawa Y, Horiai H, Ono T. The effects of TFC-612, a 7-thia prostaglandin E1 derivative, on platelet function. Thromb Res. 1991 Jul 1;63(1):29-38. PubMed PMID: 1658963. 3: Motoyama Y, Sakata Y, Seki J, Dohi M, Yoshida K. Effect of TFC-612, a 7-thia prostaglandin E1 derivative, on a peripheral arterial occlusive disease model in rats. Prostaglandins. 1995 Mar;49(3):175-82. PubMed PMID: 7652186. 4: Suzuki K, Saito N, Sakata Y, Toyota T, Goto Y. A new prostaglandin E1 analogue (TFC-612) improves the reduction in motor nerve conduction velocity in spontaneously diabetic GK (Goto-Kakizaki) rats. Prostaglandins. 1990 Nov;40(5):463-71. PubMed PMID: 2255766. 5: Yasuda H, Sonobe M, Hatanaka I, Yamashita M, Miyamoto Y, Terada M, Amenomori M, Kikkawa R, Shigeta Y, Motoyama Y, et al. A new prostaglandin E1 analogue (TFC-612) prevents a decrease in motor nerve conduction velocity in streptozocin-diabetic rats. Biochem Biophys Res Commun. 1988 Jan 15;150(1):225-30. PubMed PMID: 3276309. 6: Motoyama Y, Sakata Y, Seki J, Asada T, Namikawa Y, Horiai H, Ono T. The effects of TFC-612, a 7-THIA prostaglandin E1 derivative, on platelet function. Thromb Res. 1991 Jun 1;62(5):471-80. PubMed PMID: 1654599. 7: Motoyama Y, Sakata Y, Seki J, Sato M, Namikawa Y, Horiai H, Ono T. TFC-612, a prostaglandin E1 derivative, enhances fibrinolytic activity in rats. Thromb Res. 1992 Jan 1;65(1):55-63. PubMed PMID: 1604443. 8: Motoyama Y, Seki J, Katoh Y, Nishio M, Yoshida K. Effect of TFC-612, a 7-thia prostaglandin E1 derivative, on intimal thickening after endothelial injury with balloon catheter in rats. Atherosclerosis. 1994 Aug;108(2):159-65. PubMed PMID: 7980715. 9: Tanaka H, Minoshima T, Endo N. The effect of a synthetic 7-thiaprostaglandin E1 derivative, TEI-6122, on monocyte chemoattractant protein-1 induced chemotaxis in THP-1 cells. Br J Pharmacol. 1995 Oct;116(4):2298-302. PubMed PMID: 8564263; PubMed Central PMCID: PMC1908987. 10: Nagamatsu T, Kojima J, Ito M, Kondo N, Suzuki Y. Antinephritic effects of PGE1 and thiaprostaglandin E1, TEI-5178 and TEI-6122, on crescentic-type anti-GBM nephritis in rats. Jpn J Pharmacol. 1989 Dec;51(4):521-30. PubMed PMID: 2615044.