MedKoo Cat#: 564660 | Name: SRI-37684

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SRI-37684 is a GLUT inhibitor which preferentially inhibits the growth of GBM cells with minimal toxicity to non-neoplastic astrocytes and neurons. SRI-37684 also inhibits glucose uptake and decreases the glycolytic capacity and glycolytic reserve capacity of GBM patient-derived xenograft (PDX) cells in glycolytic stress test assays.

Chemical Structure

SRI-37684
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564660

Name: SRI-37684

CAS#: NONE

Chemical Formula: C23H18N4O2

Exact Mass: 382.1430

Molecular Weight: 382.42

Elemental Analysis: C, 72.24; H, 4.74; N, 14.65; O, 8.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SRI37684; SRI 37684; SRI-37684
IUPAC/Chemical Name
N-(4-(1H-Indol-4-yl)-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)nicotinamide
InChi Key
QPCZEOJDMQKHEV-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H18N4O2/c28-22-12-19(16-4-1-5-20-18(16)8-10-25-20)17-7-6-15(11-21(17)27-22)26-23(29)14-3-2-9-24-13-14/h1-11,13,19,25H,12H2,(H,26,29)(H,27,28)
SMILES Code
O=C(NC1=CC2=C(C=C1)C(C3=CC=CC4=C3C=CN4)CC(N2)=O)C5=CN=CC=C5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 382.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Libby CJ, Zhang S, Benavides GA, Scott SE, Li Y, Redmann M, Tran AN, Otamias A, Darley-Usmar V, Napierala M, Zhang J, Augelli-Szafran CE, Zhang W, Hjelmeland AB. Identification of Compounds That Decrease Glioblastoma Growth and Glucose Uptake in Vitro. ACS Chem Biol. 2018 Aug 17;13(8):2048-2057. doi: 10.1021/acschembio.8b00251. Epub 2018 Jun 15. PubMed PMID: 29905460.