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MedKoo Cat#: 533076 | Name: Zolimidine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Zolimidine is a histamine H₂ receptor antagonist that was investigated for its potential use in the treatment of peptic ulcers and gastric acid-related disorders. It works by blocking H₂ receptors in the stomach, thereby reducing the secretion of gastric acid and alleviating symptoms associated with ulcers and acid reflux

Chemical Structure

Zolimidine
Zolimidine
CAS#1222-57-7

Theoretical Analysis

MedKoo Cat#: 533076

Name: Zolimidine

CAS#: 1222-57-7

Chemical Formula: C14H12N2O2S

Exact Mass: 272.0619

Molecular Weight: 272.32

Elemental Analysis: C, 61.75; H, 4.44; N, 10.29; O, 11.75; S, 11.77

Price and Availability

Size Price Availability Quantity
1mg USD 385.00 2 Weeks
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Related CAS #
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Synonym
Zolimidine
IUPAC/Chemical Name
2-(4-Methylsulfonylphenyl)imidazo[1,2-a]pyridine
InChi Key
VSLIUWLPFRVCDL-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H12N2O2S/c1-19(17,18)12-7-5-11(6-8-12)13-10-16-9-3-2-4-14(16)15-13/h2-10H,1H3
SMILES Code
O=S(C1=CC=C(C2=CN3C=CC=CC3=N2)C=C1)(C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 272.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Narayan A, Patel S, Baile SB, Jain S, Sharma S. Imidazo[1,2-A]Pyridine: Potent Biological Activity, SAR and Docking Investigations (2017-2022). Infect Disord Drug Targets. 2024;24(8):e200324228067. doi: 10.2174/0118715265274067240223040333. PMID: 38509674. 2: Kamboj P, Tyagi V. Enzymatic Synthesis of Indole-Based Imidazopyridine using α-Amylase. Chembiochem. 2024 Mar 15;25(6):e202300824. doi: 10.1002/cbic.202300824. Epub 2024 Feb 20. PMID: 38279707. 3: Tyagi S, Mishra R, Mazumder R, Mazumder A. Current Market Potential and Prospects of Copper-based Pyridine Derivatives: A Review. Curr Mol Med. 2024;24(9):1111-1123. doi: 10.2174/1566524023666230726160056. PMID: 37496249. 4: Guo L, Ding Y, Wang H, Liu Y, Qiang Q, Luo Q, Song F, Li C. Imidazo[1,2-a]pyridine derivatives synthesis from lignin β-O-4 segments via a one-pot multicomponent reaction. iScience. 2023 May 9;26(6):106834. doi: 10.1016/j.isci.2023.106834. PMID: 37250767; PMCID: PMC10209544. 5: Tali JA, Shankar R. Ru(II)-Catalyzed Synthesis of Fused Imidazo[1,2-a]pyridine-chromenones and Methylene-Tethered Bis- imidazo[1,2-a]pyridines and Regioselective O-Acetoxylation of Imidazo[1,2-a]pyridines. Org Lett. 2023 May 12;25(18):3200-3205. doi: 10.1021/acs.orglett.3c00578. Epub 2023 May 4. PMID: 37140128. 6: Prasher P, Sharma M, Sharma M, Rawat DS. C3 regioselectivity: a major constraint in the drug development with imidazo[1,2-a]pyridines. Future Med Chem. 2022 Nov;14(21):1491-1494. doi: 10.4155/fmc-2022-0148. Epub 2022 Oct 3. PMID: 36189868. 7: Zozik Y, Sevim M, Lafzi F, Kilic H, Metin Ö. Magnetically recoverable nickel- palladium alloy nanocatalysts for direct C-H arylation reactions. Dalton Trans. 2021 Dec 7;50(47):17515-17523. doi: 10.1039/d1dt02985a. PMID: 34762086. 8: Tali JA, Kumar G, Singh D, Shankar R. Palladium(II) catalyzed site-selective C-H olefination of imidazo[1,2-a]pyridines. Org Biomol Chem. 2021 Nov 10;19(43):9401-9406. doi: 10.1039/d1ob01683k. PMID: 34705920. 9: Ghosh S, Khandelia T, Patel BK. Solvent-Switched Manganese(I)-Catalyzed Regiodivergent Distal vs Proximal C-H Alkylation of Imidazopyridine with Maleimide. Org Lett. 2021 Oct 1;23(19):7370-7375. doi: 10.1021/acs.orglett.1c02536. Epub 2021 Sep 20. PMID: 34543041. 10: Bhutia ZT, Panjikar PC, Iyer S, Chatterjee A, Banerjee M. Iodine Promoted Efficient Synthesis of 2-Arylimidazo[1,2-a]pyridines in Aqueous Media: A Comparative Study between Micellar Catalysis and an "On-Water" Platform. ACS Omega. 2020 May 26;5(22):13333-13343. doi: 10.1021/acsomega.0c01478. PMID: 32548520; PMCID: PMC7288711. 11: Samanta SK, Bera MK. Iodine mediated oxidative cross coupling of 2-aminopyridine and aromatic terminal alkyne: a practical route to imidazo[1,2-a]pyridine derivatives. Org Biomol Chem. 2019 Jul 14;17(26):6441-6449. doi: 10.1039/c9ob00812h. Epub 2019 Jun 17. Erratum in: Org Biomol Chem. 2019 Aug 7;17(31):7425. doi: 10.1039/c9ob90125f. PMID: 31206121. 12: Zhou G, Tian Y, Zhao X, Dan W. Selective Fluorination of 4-Substituted 2-Aminopyridines and Pyridin-2(1 H)-ones in Aqueous Solution. Org Lett. 2018 Aug 17;20(16):4858-4861. doi: 10.1021/acs.orglett.8b02003. Epub 2018 Aug 7. PMID: 30085670. 13: Deep A, Bhatia RK, Kaur R, Kumar S, Jain UK, Singh H, Batra S, Kaushik D, Deb PK. Imidazo[1,2-a]pyridine Scaffold as Prospective Therapeutic Agents. Curr Top Med Chem. 2017;17(2):238-250. doi: 10.2174/1568026616666160530153233. PMID: 27237332. 14: Wang FJ, Xu H, Xin M, Zhang Z. Ι₂-mediated amination/cyclization of ketones with 2-aminopyridines under high-speed ball milling: solvent- and metal-free synthesis of 2,3-substituted imidazo[1,2-a]pyridines and zolimidine. Mol Divers. 2016 Aug;20(3):659-66. doi: 10.1007/s11030-016-9666-y. Epub 2016 Mar 14. PMID: 26975201. 15: Zhang Y, Chen Z, Wu W, Zhang Y, Su W. CuI-catalyzed aerobic oxidative α-aminaton cyclization of ketones to access aryl or alkenyl-substituted imidazoheterocycles. J Org Chem. 2013 Dec 20;78(24):12494-504. doi: 10.1021/jo402134x. Epub 2013 Dec 3. PMID: 24256374. 16: He C, Hao J, Xu H, Mo Y, Liu H, Han J, Lei A. Heteroaromatic imidazo[1,2-a]pyridines synthesis from C-H/N-H oxidative cross- coupling/cyclization. Chem Commun (Camb). 2012 Nov 21;48(90):11073-5. doi: 10.1039/c2cc35927h. Epub 2012 Sep 27. PMID: 23019572. 17: Katsura Y, Nishino S, Takasugi H. Studies on antiulcer drugs. I. Synthesis and antiulcer activities of imidazo[1,2-alpha]pyridinyl-2-oxobenzoxazolidines-3-oxo-2H-1,4-benzoxaz ines and related compounds. Chem Pharm Bull (Tokyo). 1991 Nov;39(11):2937-43. doi: 10.1248/cpb.39.2937. PMID: 1799940. 18: Melloni R, Melloni GF, Scarazatti E. Osservazioni sul comportamento dei valori ematici di PRL, TSH, FSH, LH NELLA malattia ulcerosa gastro-duodenale in trattamento farmacologico [Behavior of blood values of prolactin, TSH, FSH, and LH in gastroduodenal ulcer during drug therapy]. Boll Soc Ital Biol Sper. 1984 Apr 30;60(4):761-7. Italian. PMID: 6234007. 19: Parodi MC, Molinari F, Barocci S. Influence of 'cytoprotective' drugs (carbenoxolone, zolimidine, prostanoic acid) on mucus secretion in patients with gastric ulcer. Scand J Gastroenterol Suppl. 1984;92:163-6. PMID: 6234649. 20: Bombardelli E, Conti M, Magistretti MJ, Martinelli EM. Computer-aided evaluation of gastric proteoglycans by high-resolution gas chromatography. J Chromatogr. 1983 Nov 25;279:593-601. doi: 10.1016/s0021-9673(01)93662-3. PMID: 6672037.

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