Synonym
CY5 NHS ester; CY 5 NHS ester; CY5-NHS ester; Cyanine5 NHS ester; Cyanine 5 NHS ester; Cyanine5-NHS ester;
IUPAC/Chemical Name
1-(6-((2,5-dioxopyrrolidin-1-yl)oxy)-6-oxohexyl)-3,3-dimethyl-2-((1E,3E)-5-((E)-1,3,3-trimethylindolin-2-ylidene)penta-1,3-dien-1-yl)-3H-indol-1-ium, tetrafluoroborate
InChi Key
LWGOCTDPEVJNTC-UHFFFAOYSA-N
InChi Code
InChI=1S/C36H42N3O4.BF4/c1-35(2)26-16-11-13-18-28(26)37(5)30(35)20-8-6-9-21-31-36(3,4)27-17-12-14-19-29(27)38(31)25-15-7-10-22-34(42)43-39-32(40)23-24-33(39)41;2-1(3,4)5/h6,8-9,11-14,16-21H,7,10,15,22-25H2,1-5H3;/q+1;-1
SMILES Code
CC1(C)/C(N(C)C2=C1C=CC=C2)=C\C=C\C=C\C3=[N+](CCCCCC(ON4C(CCC4=O)=O)=O)C5=C(C=CC=C5)C3(C)C.F[B-](F)(F)F
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
580.75
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1 Faidra Angelerou, M.G.; Markus, R.; Paraskevopoulou, V.; Foralosso, R.; Clarke, P.; Alvarez, C.V.; Chenlo, M.; Johnson, L.; Rutland, C.; Allen, S.; Brasnett, C.; Seddon, A.; Zelzer, M.; Marlow, M. Mechanistic investigations into the encapsulation and release of small molecules and proteins from a supramolecular nucleoside gel in vitro and in vivo. Journal of Controlled Release, in press. doi: 10.1016/j.jconrel.2019.10.011
2. Poreba, M.; Groborz, K.; Rut, W.; Pore, M.; Snipas, S.J.; Vizovisek, M.; Turk, B.; Kuhn, P.; Drag, M.; Salvesen, G.S. The Activome: multiplexed probing of activity of proteolytic enzymes using mass cytometry-compatible activity-based probes (TOF-probes). bioRxiv, preprint. doi: 10.1101/775627
3. Samaridou, E.; Kalamidas, N.; Santalices, I.; Crecente-Campo, J.; Alonso, M.J. Tuning the PEG surface density of the PEG-PGA enveloped Octaarginine-peptide Nanocomplexes. Drug Delivery and Translational Research, in press. doi: 10.1007/s13346-019-00678-3
4. Hofmann, F.J.; Bodnarchuk, M.; Dirin, D.N.; Vogelsang, J.; Kovalenko, M.V.; Lupton, J.M. Energy transfer from perovskite nanocrystals to dye molecules does not occur by FRET. Nano Letters, in press. doi: 10.1021/acs.nanolett.9b03779
