MedKoo Cat#: 533036 | Name: ES9-17
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ES9-17 is a novel Clathrin-mediated endocytosis (CME) inhibitor, targeting clathrin heavy chain (CHC).

Chemical Structure

ES9-17
ES9-17
CAS#55854-43-8

Theoretical Analysis

MedKoo Cat#: 533036

Name: ES9-17

CAS#: 55854-43-8

Chemical Formula: C10H8BrNO2S2

Exact Mass: 316.9180

Molecular Weight: 318.20

Elemental Analysis: C, 37.75; H, 2.53; Br, 25.11; N, 4.40; O, 10.06; S, 20.15

Price and Availability

Size Price Availability Quantity
25mg USD 250.00 2 Weeks
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 2,250.00 2 Weeks
1g USD 3,250.00 2 Weeks
2g USD 5,450.00 2 Weeks
5g USD 7,650.00 2 Weeks
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Related CAS #
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Synonym
ES9-17; ES9 17; ES917
IUPAC/Chemical Name
5-Bromo-N-phenylthiophene-2-sulfonamide
InChi Key
AIZXCKZVUXCHAP-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H8BrNO2S2/c11-9-6-7-10(15-9)16(13,14)12-8-4-2-1-3-5-8/h1-7,12H
SMILES Code
O=S(C1=CC=C(Br)S1)(NC2=CC=CC=C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 318.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Dejonghe W, Sharma I, Denoo B, De Munck S, Lu Q, Mishev K, Bulut H, Mylle E, De Rycke R, Vasileva M, Savatin DV, Nerinckx W, Staes A, Drozdzecki A, Audenaert D, Yperman K, Madder A, Friml J, Van Damme D, Gevaert K, Haucke V, Savvides SN, Winne J, Russinova E. Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. Nat Chem Biol. 2019 Jun;15(6):641-649. doi: 10.1038/s41589-019-0262-1. Epub 2019 Apr 22. PMID: 31011214; PMCID: PMC7612312. 2: Oliveira-Garcia E, Hamilton AJ. A pharmacological approach to investigating effector translocation in rice-Magnaporthe oryzae interactions. Plant Signal Behav. 2024 Dec 31;19(1):2350869. doi: 10.1080/15592324.2024.2350869. Epub 2024 May 9. PMID: 38722963; PMCID: PMC11085958. 3: Zhang L, Zhang M, Yong K, Zhang L, Wang S, Liang M, Yan B, Li H, Cao L, Lu M. SlECA4, an epsin-like clathrin adaptor protein, improves tomato heat tolerance via clathrin-mediated endocytosis. J Exp Bot. 2024 Dec 4;75(22):7031-7045. doi: 10.1093/jxb/erae386. PMID: 39269332.