MedKoo Cat#: 555671 | Name: (RS)-MCPG
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

(RS)-MCPG is a Non-selective mGlu antagonist.

Chemical Structure

(RS)-MCPG
(RS)-MCPG
CAS#146669-29-6

Theoretical Analysis

MedKoo Cat#: 555671

Name: (RS)-MCPG

CAS#: 146669-29-6

Chemical Formula: C10H11NO4

Exact Mass: 209.0688

Molecular Weight: 209.20

Elemental Analysis: C, 57.41; H, 5.30; N, 6.70; O, 30.59

Price and Availability

Size Price Availability Quantity
100mg USD 950.00 2 Weeks
200mg USD 1,650.00 2 Weeks
500mg USD 2,250.00 2 Weeks
1g USD 3,250.00 2 Weeks
2g USD 5,450.00 2 Weeks
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Related CAS #
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Synonym
(RS)-MCPG; (RS) MCPG; (RS)MCPG
IUPAC/Chemical Name
4-(1-amino-1-carboxyethyl)benzoic acid
InChi Key
DNCAZYRLRMTVSF-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)
SMILES Code
NC(C)(C1=CC=C(C=C1)C(O)=O)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 209.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Heynickx N, Segers C, Coolkens A, Baatout S, Vermeulen K. Characterization of Non-Specific Uptake and Retention Mechanisms of [177Lu]Lu-PSMA-617 in the Salivary Glands. Pharmaceuticals (Basel). 2023 May 3;16(5):692. doi: 10.3390/ph16050692. PMID: 37242475; PMCID: PMC10224201. 2: Longhi-Balbinot DT, Pietrovski EF, Gadotti VM, Martins DF, Facundo VA, Santos AR. Spinal antinociception evoked by the triterpene 3beta, 6beta, 16beta- trihydroxylup-20(29)-ene in mice: evidence for the involvement of the glutamatergic system via NMDA and metabotropic glutamate receptors. Eur J Pharmacol. 2009 Nov 25;623(1-3):30-6. doi: 10.1016/j.ejphar.2009.09.004. Epub 2009 Sep 15. PMID: 19765585. 3: Kim JH, Vezina P. The metabotropic glutamate receptor antagonist (RS)-MCPG produces hyperlocomotion in amphetamine pre-exposed rats. Neuropharmacology. 1998;37(2):189-97. doi: 10.1016/s0028-3908(98)00015-x. PMID: 9680243. 4: Kim JH, Vezina P. Metabotropic glutamate receptors are necessary for sensitization by amphetamine. Neuroreport. 1998 Feb 16;9(3):403-6. doi: 10.1097/00001756-199802160-00008. PMID: 9512379. 5: Lohr C, Deitmer JW. Intracellular Ca2+ release mediated by metabotropic glutamate receptor activation in the leech giant glial cell. J Exp Biol. 1997 Oct;200(Pt 19):2565-73. doi: 10.1242/jeb.200.19.2565. PMID: 9366087. 6: Dubé GR, Marshall KC. Modulation of excitatory synaptic transmission in locus coeruleus by multiple presynaptic metabotropic glutamate receptors. Neuroscience. 1997 Sep;80(2):511-21. doi: 10.1016/s0306-4522(97)00004-3. PMID: 9284353. 7: Emile L, Mercken L, Apiou F, Pradier L, Bock MD, Menager J, Clot J, Doble A, Blanchard JC. Molecular cloning, functional expression, pharmacological characterization and chromosomal localization of the human metabotropic glutamate receptor type 3. Neuropharmacology. 1996 May;35(5):523-30. doi: 10.1016/0028-3908(96)84622-3. PMID: 8887960.