Benzamil HCl is a derivative of amiloride. Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from and binds to kidney cortex membrane vesicles. It is also an inhibitor of the Na+/Ca2+ exchanger (NCX) that inhibits the cytosolic calcium response to extracellular sodium depletion. Benzamil inhibits transient receptor potential polycystin-L (TRPP3) -- a member of the TRP superfamily of cation channels.
MedKoo Cat#: 573994
Name: Benzamil HCl
CAS#: 161804-20-2
Chemical Formula: C13H15Cl2N7O
Exact Mass: 355.0715
Molecular Weight: 356.21
Elemental Analysis: C, 43.83; H, 4.24; Cl, 19.90; N, 27.53; O, 4.49
The following data is based on the product molecular weight 356.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
