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MedKoo Cat#: 563253 | Name: RID-F

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RID-F is a nonpeptidic proteasome inhibitor.

Chemical Structure

RID-F
RID-F
CAS#1020853-03-5

Theoretical Analysis

MedKoo Cat#: 563253

Name: RID-F

CAS#: 1020853-03-5

Chemical Formula: C38H50N2O2

Exact Mass: 566.3872

Molecular Weight: 566.83

Elemental Analysis: C, 80.52; H, 8.89; N, 4.94; O, 5.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
RID-F; RID F; RIDF; Ridaifen-F; Ridaifen F;
IUPAC/Chemical Name
1,1'-[(2-Phenyl-1-buten-1-ylidene)bis(4,1-phenyleneoxy-2,1-ethanediyl)]bis[hexahydro-1H-azepine]
InChi Key
CVNPFNZJSHRZFA-UHFFFAOYSA-N
InChi Code
InChI=1S/C38H50N2O2/c1-2-37(32-14-8-7-9-15-32)38(33-16-20-35(21-17-33)41-30-28-39-24-10-3-4-11-25-39)34-18-22-36(23-19-34)42-31-29-40-26-12-5-6-13-27-40/h7-9,14-23H,2-6,10-13,24-31H2,1H3
SMILES Code
CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN3CCCCCC3)C=C2)\C4=CC=C(OCCN5CCCCCC5)C=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 566.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tanaka M, Zhu Y, Shionyu M, Ota N, Shibata N, Watanabe C, Mizusawa A, Sasaki R, Mizukami T, Shiina I, Hasegawa M. Ridaifen-F conjugated with cell-penetrating peptides inhibits intracellular proteasome activities and induces drug-resistant cell death. Eur J Med Chem. 2018 Feb 25;146:636-650. doi: 10.1016/j.ejmech.2018.01.045. Epub 2018 Jan 31. PubMed PMID: 29407987. 2: Cohen JM, Teeguarden JG, Demokritou P. An integrated approach for the in vitro dosimetry of engineered nanomaterials. Part Fibre Toxicol. 2014 May 1;11:20. doi: 10.1186/1743-8977-11-20. PubMed PMID: 24885440; PubMed Central PMCID: PMC4024018. 3: Hasegawa M, Yasuda Y, Tanaka M, Nakata K, Umeda E, Wang Y, Watanabe C, Uetake S, Kunoh T, Shionyu M, Sasaki R, Shiina I, Mizukami T. A novel tamoxifen derivative, ridaifen-F, is a nonpeptidic small-molecule proteasome inhibitor. Eur J Med Chem. 2014 Jan;71:290-305. doi: 10.1016/j.ejmech.2013.11.009. Epub 2013 Nov 16. PubMed PMID: 24321833.